2015年2月第37卷第4期HebeiMedicalJournal,2015,Vol37FebNo..42011,9:211-212.6SandstedeJ,LipkerC,BeerM,eta1.Ageandgender-specificdifferencesinleftandfightventrieularcardiacfunctionandmassdeterminedbycinemagneticresonanceima~ng.EurRadiol,2000,10:438-442.7张笑春,杨志刚,郭应坤,等.健康成人左右心室整体心功能的64排doi:10.3969/j.issn.1002-7386.2015.04.003491螺旋CT研究.生物医学工程杂志,2010,27:297-301.8DanneabergAL,LevyD,GarrisonRJ,eta1.Impactofageonechocardio—graphicLVMinaheahhypopulation'(theFraminghamStudy).AmJCar-diol,1996,64:1066—1068.(收稿日期:2014—09—22)幽门螺杆菌和眼底动脉硬化与冠心病相关性分析李世敬华琦王德昭【摘要】目的探讨幽门螺杆菌(helicobacterpylori,H.pylori)感染和眼底动脉硬化(OFA)与冠状动脉粥样硬化性心脏病(CAD)的相关性。方法根据冠状动脉造影(CAG)的结果,将305例研究对象分为非CAD组和CAD组。所有病例均行”c.呼气试验、血浆H.pylori抗体(H.pyloriIgG)测定及眼底动脉检查;同时收集病史、血常规、血生化、尿微量白蛋白(UMA)、高敏C反应蛋白(hs—CRP)、糖化血红蛋白水平等指标,评价H.pylori感染、OFA与CAD的相关性。结果CAD组”C呼气试验H.pylori感染、OFA阳性率明显高于非CAD组(P<0.05);CAD组c呼气试验H.pylofi感染8值明显高于非CAD组(P<0.05)。综合H.pylori感染、眼底动脉硬化程度及其他危险因素后,发现H.pyloriI>4%o、OFAI>II级、糖尿病、年龄t>65岁与CAD具有较强的相关性(P<0.05)。结论H.pylori感染、OFA与CAD具有一定的相关性。【关键词】幽门螺杆菌感染;眼底动脉硬化;冠状动脉粥样硬化性心脏病;13C呼气试验【中图分类号】R541.4【文献标识码】A【文章编号】1002—7386(2015)04—0491—04TherelationshipbetweenHelicobacterpyloriandocularfundusarteriosclerosisaswellascoronaryatheroscleroticheartdiseaseL/Shqing,HUAQi,WANGDezhao.DepartmentofCardiology,MentougouDistrictHospitalofBeijirtg,ng102300,China一【Abstract】objectiveToinvestigatethecorrelationbetweenHelicobacterpylori(Hp)infectionandcoronaryatheroscleroticheartdisease(CAD)aswellasocularfundusarteriosclerosis(OFA).MethodsAccordingtotheresultsofthecoronaryangiography(CAG),the305patientsweredividedintonon—CADgroupandCADgroup,allthepatientsunderwent”C-breathtest,HpIgGantibodydeterminationandOFA,atthesametime,thepatien’scasehigt0rywascolleted,microalbuminuria(UMA),highsensitivityC-reactiveprotein(Hs-CRP)weredetectedandbloodroutinetest,biochemicalparameterexamination,glycosylatedhemoglobintestwereperformedtoevaluatethecorrelationbetweenHpinfectionandOFAaswellasCAD.ResultsAccordingtotheresultsof”C—breathtest.th。positiveratesofHpinfectioninCADgroupweresignificantlyhigherthanthoseinnon—CADgroup(P<0.05),atthesametime,the8valueofHpinfectioninCADgroupwassignificantlyhigherthanthatinnon—CADgroup(P<0.05).TherewasaclosecorrelationbetweenCADandHp≥4%。,OFA≥Ugrade,diabetesmellitus,aget>65years(P<0.05).ConclusionHpinfectioniscorrelatedwithOFAandCADat。someextent..【Keywords】helicobacterpriori;ocularfundusarteriosclerosis;coronaryheartdiseabe;13C-breathtest随着人们生活水平的提高,冠状动脉粥样硬化性心脏病(CAD)的发病率逐渐升高,且越来越年轻化,尽早了解冠状动脉病变情况,及时预防和治疗至关重要。冠状动脉造影作为诊断CAD的金标准,费用较高,且有创,不易普及。眼底动脉硬化(OFA)是人体项目来源:北京市优秀青年基金项目(编号:201119008017000002)作者单位:102300北京市门头沟区医院心内科(李世敬);首都医科大学宣武医院心内科(华琦);首都医科大学附属北京天坛医院心内科(王德昭)通讯作者:王德昭,100050首都医...