中国神经免疫学和神经病学杂志2O15年5月第22卷第3期ChinJNeuroimmunol＆Neurol2015．V01．22．No．3幽门螺杆菌感染与血管性痴呆患者血清炎性标志物的相关性王新王康琪董燕摘要：目的探讨幽门螺杆菌(Hp)感染与血管性痴呆(VD)患者血清炎性标志物的相关性及其参与VD发病的可能机制。方法收集88例临床诊断VD患者及76名健康体检者的临床资料，以尿素呼气试验阳性作为现症Hp感染诊断指标，血清Hp抗体阳性为慢性Hp感染诊断指标，同时检测高敏c反应蛋白(hs—CRP)、肿瘤坏死因子一(TNF—a)、白细胞介素6(IL一6)3种血清炎性反应标志物。结果VD患者Hp感染率及hs—CRP、TNF_“、IL一6水平均显著高于对照组(P<0．01)，多元回归分析结果显示hs—CRP及Hp现症和慢性感染并存与VD相关性较强(OR一3．855，95CI=1．648～7．682；OR=3．949，95CI=1．946～8．061)。结论Hp感染与VD有一定相关性，Hp感染可能通过激发急性炎性反应而导致VD的发展。关键词：痴呆，血管性；螺杆菌，幽门；肿瘤坏死因子一a；白细胞介素6；C反应蛋白质中图分类号：R743．9文献标识码：A文章编号：1006—2963(2015)030191—04Relevancebetweenseruminflammatorybiomarkersinpatientswithvasculardementiaandhelicobacterpyloriinfec—tionWANGXin，WANGKangqi，DONGYan．DepartmentofNeurology，TheSecondPeople’5Hos—pitalofLianyungang，LianyungangJiangsu222006，ChinaC。rrespondingauthor：WANGXin，Email：zhj6041@163．cornABSTRACT：objectiveToexploretherelationshipbetweenseruminflammatorybiomarkersinpatientswithvasculardementia(VD)andhelicobacterpylori(Hp)infection．MethodsEighty-eightVDpatientsand76healthysubjectswereenrolled．ThepositiveC—ureabreathtestandHpantibody(Hp—IgG)wereusedasdiagnosisindicatorsofpresentandchronicHpinfection．ThreeinflammatorycytokinessuchashighsensitivityC—reactiveprotein(hs～CRP)，tumornecrosisfactora(TNFd)，andinterleukin一6(IL6)weredetected．ResultsInVDpatients，therateofpresentHpinfectionwassignificantlyhigherthanthatofhealthysubjects(P
