�临床研究�听神经病患者失匹配负波特征与言语识别率的关系*郭明丽1�周娜1�兰兰1�陈之慧1�于黎明1�王秋菊1�杨伟炎1��摘要!�目的�观察听神经病(auditoryneuropathy,AN)患者失匹配负波(mismatchnegativity,MMN)的基本特征及其与最大言语识别率(phoneticbalancedmaximum,PBmax)的关系。方法�用IHS3099(Version3.82)型诱发电位仪对14例(19耳)AN患者和24例(24耳)听力正常者行MMN测试,用GSI-61双通道诊断型听力计和SONYTc-Fx25盒式双声道立体声录音机及自行录制的单音节音素平衡词表磁带分别测试14例(19耳)AN患者和19例(19耳)听力正常者的PBmax,比较两组MMN潜伏期和振幅差异有无显著性意义,并分析MMN潜伏期和振幅与PBmax的相关性。结果�与对照组相比,AN组MMN(强度差异和频率差异)潜伏期显著延长(P<0.01),AN组强度差异MMN振幅与对照组相比有显著性差异(P=0.019),两组频率差异MMN振幅无显著性差异(P=0.128);AN组频率差异和强度差异MMN潜伏期与PBmax呈部分负相关(r=-0.647,P<0.01;r=-0.708,P<0.01),对照组强度差异MMN潜伏期与PBmax也呈部分负相关(r=-0.643,P<0.05),但对照组频率差异MMN潜伏期与PBmax无相关性(r=-0.027,P=0.913)。结论�MMN潜伏期相对稳定,振幅变异较大。AN组MMN潜伏期明显比对照组延长,在群体水平与PBmax呈部分负相关。MMN潜伏期在预估AN患者的言语识别能力方面有一定的意义。关键词!�听神经病;�失匹配负波;�最大言语识别率中图分类号!�R764.4��文献标识码!�A��文章编号!�1006-7299(2006)01-0016-05TheCharacteristicofMismatchNegativityandtheRelationshipBetweenMismatchNegativityandSpeechPerceptioninPatientswithAuditoryNeuropathyGuoMingli,ZhouNa,LanLan,etal.(DepartmentofOtorhinolaryngologyandHead&NeckSurgery,GeneralHospitalofPLA,Beijing,100853,China)��Abstract!�Objective�Toobservethebasiccharacteristicofmismatchnegativity(MMN)andtherelationshipbetweenMMNandphoneticbalancedmaximum(PBmax)inpatientswithauditoryneuropathy(AN).Methods�TheMMNof14ANpa�tients(19ears)and24subjects(24ears)withnormalhearingwereexaminedwithSMARTEPofIHS3099(Version3.82).ThePBmaxof14ANpatients(19ears)and19subjects(19ears)withnormalhearingweretestedwithGSI-61clinicalaudiometerfedwithstereocassetteDeckTc-Fx25(SONY)andpresentedwith50s-phoneticbalancedtestlist.ThelatencyandamplitudeofMMNandPBmaxofbothgroupswereanalyzed.Results�ThepeaklatencyofMMN(frequencydifferenceandintensitydiffer�ence)intheANgroupwassignificantlylongerthanthatinthecontrolgroup(P<0.01).Incomparisonwiththecontrolgroup,theamplitudeofMMNevokedbyintensitydifferencewassignificantlychangedintheANgroup(P=0.019),buttheamplitudeofMMNevokedbyfrequencydifferencewasunchangedintheANgroup(P=0.128).TheMMNlatency(frequencydifferenceandintensitydifference)wasnegativelycorrelatedwithPBmaxintheANgroup(r=-0.647,P<0.01;r=-0.708,P<0.01).ThelatencyofMMNevokedbyintensitydifferencewasalsonegativelycorrelatedwithPBmaxinthecontrolgroup(r=-0.643,P<0.05),butthelatencyofMMNevokedbyfrequencydifferencehadnocorrelationwiththePBmaxinthecontrolgroup(r=-0.027,P=0.913).Conclusion�ThelatencyofMMNisrelativelystable,buttheamplitudeofMMNisvariable.ThelatencyofMMNissignificantlylongerthanthatinthecontrolgroupandisnegativelycorrelatedwithPBmaxatgrouplevelintheANgroup.ItsuggeststhatMMNlatencytestingmayofferameansofpredictingspeechperception.Keywords!�Mismatchnegativity;�Auditoryneuropathy;�Phoneticbalancedmaximum*�国家自然科学基金面上项目(30370782及30470956)和国家∀863#面上项目(2004AA221080)、北京市重大科技项目(H020220020610)联合资助1�解放军总医院耳鼻咽喉-头颈外科(北京�100853)作者简介:郭明丽,女,河北人,副主任医师,在读博士研究生,主要研究方向为临床...
