从药品不良事件谈临床药师对肿瘤患者的用药监护蔡和平，王 卓*，黄 瑾，徐慧欣，杨 黎（第二军医大学长海医院药学部，上海 200433）【摘要】目的：分析第二军医大学长海医院抗肿瘤药品不良事件(ADE)的发生情况及其规律，寻找临床药师对肿瘤患者用药监护的要点，提高抗肿瘤药物的合理用药水平。方法：2004 年～2009 年全院上报的 108 例抗肿瘤 ADE 病例报告进行分类频数统计和分析评价，提出临床药师用药监护点。结果：发生 ADE 的病例中男性居多。用药当日发生 ADE 的比例最高。抗肿瘤药物中 ADE 发生率排居前三位的分别为：奥沙利铂、甲氨蝶呤与紫杉醇。抗肿瘤药物 ADE 累及系统器官排居前三位的为：中枢神经系统、消化系统及免疫系统。结论：临床药师应重点关注肿瘤患者用药人群、抗肿瘤药物 ADE 发生时间及抗肿瘤药物 ADE 累及的器官及表现。通过加强临床药师对抗肿瘤药物用药过程的观察和监护，减少 ADE 的发生及其造成的损害，促进合理用药。【关键词】抗肿瘤药物；药品不良事件；用药监护；合理用药Pharmaceutical care points on tumor patient—— discussion from adverse drug events of antineoplastic medicineCAI He-ping，WANG Zhuo*，HUANG Jin，YANG Li( Department of Pharmacy，Changhai Hospital , Second Military Medical University, Shanghai 200433，China )[ABSTRACT] Objective：To analyze the characteristics and the regularity of the antineoplastics drug induced adverse drug events (ADE) in Changhai hospital of Second Military Medical University; discuss the pharmaceutical care point of clinical pharmacist, so as to provide reference for clinical safe and rational medication. Methods：A total of 108 cases of ADE reports collected by ADE monitoring center in the hospital in 2004 to 2007 were classified and analyzed statistically. Then summarize the pharmaceutical care points on tumor patient by clinical pharmacist. Results：Male showed the higher proportions of ADE than female. ADE occured most often on the first day. In the antineoplastics medicines, methopterin, oxaliplatin and pa...
