喉部鼻型NKT细胞淋巴瘤一例临床分析并文献复习教学VIP免费

喉部鼻型 NK/T 细胞淋巴瘤一例临床分析并文献复习Phundreimayum Raees Ahmed1，谢敏2【摘要】目的 研究喉部鼻型 NK/T 细胞淋巴瘤的临床表现、 病理特点及免疫表型，提高对本病的认识。方法 对收治的 1 例喉部鼻型 NK/T 细胞淋巴瘤进行介绍，并对 2001 年至 2012 年国内发表的该病报道进行回顾性分析。结果 纳入 8 篇报道共 10 例确诊为喉部鼻型NK/T 细胞淋巴瘤患者。 患者多中年起病， 临床表现多样，最常见首发症状为声音嘶哑（80%）。病变最常累及的部位为声带（87.5%），出现表面增生或浸润性肿块（85.7%）、粘膜肿胀（ 57.1%）。其镜下最常见表现为大片坏死组织， 淋巴细胞增生活跃 （55.6%）。免疫组化 CD45RO、TIA-1 、EBER1/2的阳性率均为 100%，而 CD56、粒酶 B 的阳性率为 75%。结论 喉部鼻型 NK/T 细胞淋巴瘤的临床表现多样，但其具有独特的病理、免疫学特点。【关键词】喉部；鼻型NK/T 细胞淋巴瘤；临床分析Clinical Analysis of 1 Case of Laryngeal Nasal-NK/T-Cell Lymphoma with Literature Review PHUNDREIMAYUM Raees Ahmed1, XIE Min2 1 Department of Respiration, Jawaharlal Nehru Hospital, Imphal, Manipur, India 2 Department of Respiration, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China Abstract Objective: To improve the understanding of Laryngeal Nasal-NK/T-Cell Lymphoma by analyzing its clinical, pathological and immunohistochemical characteristics. Methods: Full description of 1 case of laryngeal nasal-NK/T-cell Lymphoma was given, and domestic reports of it between year-2001 to 2012 were retrospectively analyzed. Results: 8 reports with 10 cases were collected. Most patients were affected in their middle age (90%) with onset age varied around 39.0 ( ±10.6) years old, and died of peripheral respiratory failure. Most common initial symptom was hoarseness (80%). Patients’ clinical manifestations varied, which included hoarseness (80%), sore throat or foreign body sensation (70%), fever (50%), hemoptysis (40%) and so...