下载后可任意编辑事件相关电位Ｐ３００对老年糖尿病患者的改变及意义_事件相关电位事件相关电位Ｐ３００对老年糖尿病患者的改变及意义_事件相关电位 文章编号：1005-619X（20XX）09-0554-02 【摘 要】 目的 讨论老年糖尿病患者事件相关电位 P300 的改变与病程、糖代谢及并发症的关系。方法 采纳听觉 oddball 序列刺激的诱发电位方法对 50 例糖尿病人及 30 例健康老人进行测试。MMSE 评定两组认知功能。结果 老年糖尿病人在记忆力、注意和计算力、定向力较对比组降低；糖尿病组与对比组比较，糖尿病并腔隙性脑梗死组与无脑梗死组比较 P300 波埋伏期显著延长，P300 波波幅显著降低，糖尿病组P300 波埋伏期和波幅与病程长短、糖化血红蛋白及有无高血压无明显相关。结论 老年糖尿病人比正常老年人 P300 波埋伏期明显延长，P300 波波幅明显降低，合并腔隙性脑梗死可能是 P300 波改变的主要原因之一。 【关键词】 糖尿病；老年人；P300 认知电位；认知功能 【 Abstract 】 Objective To investigate P300 cognitive potentialsinelderly diabetes and related factors. Methods 50 patients with diabetes mellitus and 30 control elderly subjects were tested on auditory induced potentials. Results There were significant differences in amplitude and latency of P300 between patients group and control group. Significant differences between patients with lacuna infarction and patients without lacuna infarction were also found. Amplitude and latency of P300 in patients were not correlated with the disease course, glycated hemoglobin and hypertension. Conclusion The effect of latency delays and amplitude reduction of P300 was much more obvious in elderly diabetes than in healthy elderly people and lacuna infarction may play an important role. 【 Key words 】 Diabetes mellitus;Elderly;P300 cognitive 1下载后可任意编辑potential;Cognitive function 糖尿病是老年人常见的慢性疾病，其在认知功能方面表现的慢性进行性的大脑功能障碍，不仅影响病人的生活质量和治疗，还带来许多社会问题。事件相关电位 P300 是目前评定认知功能的一项...
