PCT、IL-6 对脓毒症早期诊断价值的meta分析【摘要】目的： 探讨 PCT、 IL-6 对脓毒症早期的临床诊断价值。方法： 根据关键词检索文献后，按照纳入标准和排除标准进行文献筛选，利用R2.15.1 软件对收集到的文献数据进行Meta 分析。采用异质性检验方法，计算各生物标志物检验脓毒症的敏感度和特异度。结果： 根据搜索策略检索到480 篇相关文献，筛选后有 22 篇文献入选，其中包括中文文献13 篇，英文文献9 篇，异质性检验结果显示各组文献间差异具有统计学意义（χ2 值=33.25，P<0.05），对文献的meta分析结果表明： PCT 和 IL-6 是最具有检测价值的生物标记物，其中，PCT对脓毒症诊断的敏感度和特异度分别为84.1%和 80.2%，而 IL-6 的相应数据分别为 80.2%和 77.4%。结论： 降钙素原对脓毒症的早期诊断具有较高的临床价值，同时配合IL-6 诊断，能够进一步提高对脓毒症早期诊断的敏感度和特异度。【关键词 】脓毒症， PCT，IL-6 ，敏感度，特异度Analysis of PCT, IL-6 in early diagnosis of sepsis in meta Abstract: Objective: To investigate the clinical diagnostic value of PCT, IL-6 in sepsis early. Methods: according to the keywords retrieval literature, in accordance with the inclusion criteria and exclusion criteria for literature screening, the collected data using R2.15.1 software by Meta analysis. The test method for heterogeneous, various biomarkers for calculation of the sensitivity and specificity of. Results: according to the search strategy of 480 relevant literatures were collected, 22 papers were selected, including 13 Chinese papers, 9 English literatures, heterogeneity test results showed statistically significant differences between the groups of literature ( χ 2 =33.25, P<0.05), meta analysis of the literature suggests that PCT and IL-6 are biological markers, most has the value of detection of PCT among them, were 84.1% and 80.2% for sepsis diagnostic sensitivity and specificity, and IL-6 on sepsis diagnostic sensitivity and specificity were 8...
