精品文档---下载后可任意编辑ATP 竞争性 mTOR 抑制剂的设计合成与活性讨论的开题报告【摘要】ATP 竞争性 mTOR 抑制剂是一种重要的抗肿瘤药物，其从设计、合成到活性讨论都是热点领域。本讨论拟从结构基础入手，设计一系列新型化合物，并通过有机合成方法进行合成。随后，通过活性评价，筛选出具有较高活性的化合物。最终，通过药物作用机理讨论，分析化合物的作用机制。【关键词】ATP 竞争性 mTOR 抑制剂；设计；合成；活性评价；药物作用机理【Abstract】ATP competitive mTOR inhibitors are important anti-cancer drugs, and their design, synthesis and activity research are hot topics. In this study, we plan to start from the structural basis, design a series of novel compounds, and synthesize them through organic synthesis methods. Then, by activity evaluation, screen out compounds with higher activity. Finally, by studying the mechanism of drug action, analyze the mechanism of action of compounds.【Keywords】ATP competitive mTOR inhibitors; Design; Synthesis; Activity evaluation; Mechanism of drug action
