精品文档---下载后可任意编辑poly（I：C）对碘过量诱发 NOD 鼠自身免疫性甲状腺炎的影响的开题报告摘要：本文旨在探究多肽 I（poly（I：C））对于碘过量诱发的 NOD 鼠自身免疫性甲状腺炎的影响。首先，使用碘盐饮水法诱发 NOD 鼠甲状腺炎模型，并将其随机分为对比组、模型组和多肽 I 处理组。通过实验观察不同组别下 NOD 鼠的体重、甲状腺指数、免疫球蛋白、T 细胞亚群及甲状腺相关因子等指标的变化情况，以评估多肽 I 对 NOD 鼠自身免疫性甲状腺炎的影响。结果表明，与模型组相比，多肽 I 处理组的体重、甲状腺指数、甲状腺球蛋白、T 细胞亚群以及甲状腺相关因子等指标呈现出更好的恢复状态，表明多肽 I 可有效地改善 NOD 鼠自身免疫性甲状腺炎的病态。关键词：多肽 I；自身免疫性甲状腺炎；NOD 鼠；碘过量Abstract:The purpose of this study is to investigate the effect of poly (I: C) on iodine-induced autoimmune thyroiditis in NOD mice. First, the iodine-salt drinking water method was used to induce the model of thyroiditis in NOD mice, and it was randomly divided into control group, model group and poly (I: C) treatment group. Through experimental observation of the changes in body weight, thyroid index, immunoglobulin, T cell subset and thyroid-related factors in NOD mice in different groups, the effect of poly (I: C) on autoimmune thyroiditis in NOD mice was evaluated. The results showed that compared with the model group, the poly (I: C) treatment group showed better recovery in weight, thyroid index, thyroid globulin, T cell subset, and thyroid-related factors, indicating that poly (I: C) can effectively improve the pathological condition of autoimmune thyroiditis in NOD mice.Keywords:poly (I: C); autoimmune thyroiditis; NOD mouse; iodine excess
