精品文档---下载后可任意编辑不饱和薄荷醇类似物脂肪酸酯类两亲性经皮吸收促进剂促透活性讨论的开题报告摘要：经皮吸收促进剂可以增加药物穿过皮肤的渗透性，改善治疗效果。本讨论旨在探究不饱和薄荷醇类似物和脂肪酸酯类两亲性经皮吸收促进剂的促透活性。讨论将利用海内外已有的相关文献和实验数据，手动筛选出相关资料并进行归纳总结，整理出各类促透剂的特点及效果，并对两类经皮吸收促进剂的作用机理及促透活性进行探究，寻找可能存在的促透效果的协同作用。估计本讨论的结果对经皮递送系统的设计和制备具有重要意义。关键词：经皮吸收促进剂； 不饱和薄荷醇类似物； 脂肪酸酯类； 两亲性； 促透活性Abstract：Permeation enhancers can increase the permeability of drugs through the skin and improve the therapeutic effect. The purpose of this study is to explore the promoting activity of unsaturated menthol analogues and lipid ester amphiphilic permeation enhancers. The study will use relevant literature and experimental data from home and abroad to manually screen out relevant materials and summarize the characteristics and effects of various enhancers, and explore the mechanism and promoting activity of the two types of permeation enhancers, and seek the possible synergistic effect of the promoting effect. The results of this study are expected to be of great significance for the design and preparation of transdermal delivery systems.Keywords: Permeation enhancers；unsaturated menthol analogues；lipid ester；amphiphilic；promoting activity
