活心方加载治疗对冠心病患者炎性因子的影响及相关机制研究 中文摘要目的 1、本研究采用随机、对照方法，观察活心方加载治疗对气虚血瘀型冠心病患者的临床中医症候积分、生活质量表积分及炎性相关因子（IL-18、MMP-9、PPAR-γ）的疗效作用。In this study, a randomized and controlled method was used to observe the therapeutic effects of live-heart-loaded therapy on TCM syndromes, scores of quality of life and inflammatory correlation factors (IL-18, MMP-9, ppar-γ) in patients with coronary heart disease with QI deficiency and blood stasis.2、通过培养体外心肌细胞，观察缺氧条件下活心方加载干预后，心肌细胞 IL-18、MMP-9、PPAR-γ、HIF-1α 基因表达的变化，来探讨活心方对缺氧心肌细胞的影响，是否能抑制其炎症反应及提高缺氧心肌细胞活性的作用。Observing the effect of living heart on hypoxia cardiomyocytes, and whether it could inhibit the inflammatory reaction and enhance the activity of hypoxia cardiomyocytes by culturing cardiomyocytes in vitro and observe the changes of IL-18, MMP-9, PPAR-γ and hif-1α gene expression in cardiomyocytes were studied.方法1、临床部分：本研究通过随机对照的方法，将符合为冠心病气虚血瘀型的患者 60 例，随机分为活心方加载组（简称治疗组）及常规治疗组（简称对照组），每组各 30 例，常规治疗组给予单纯西药治疗，活心方加载组则在常规西药治疗的基础上加服活心方（免煎颗粒剂），3 个月为一疗程，分别在治疗前、治疗后检测患者血清IL-18、MMP-9、PPAR-γ 指标，记录中医症候积分、进行生活质量评价，并整理数据，进行统计分析，对结果分析讨论。The part of clinic: In this study, 60 patients with coronary heart disease with QI deficiency and blood stasis were treated by randomized controlled method, randomly divided into live heart loading group (referred to as the treatment group) and conventional treatment group (referred to as the control group), each group of 30 cases, the conventional treatment group to give simple Western medicine...
