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AntibodiesfortheDiagnosticsIndustryAntibodiesforDiagnosticsfromRocheCustomBiotechProductsareforfurtherprocessingonly.TrademarksCOBASandELECSYSaretrademarksofRoche.Otherbrandsorproductnamesaretrademarksoftheirrespectiveholders.Diagnosticsmanufacturersrequireantibodiesandantibodymixesofprovenqualityspecificallyproducedforuseindiagnostickits.RocheCustomBiotechoffersadedicatedproductlineofhigh-qualityantibodiesforuseinclinicalchemistryandimmuno-logicalapplications,suchasthyroiddiagnostics,tumormarkers,andfertilitytesting.AllRocheantibodies:arespecificallydevelopedfordiagnostickitshaveguaranteedspecifications,stability,andavailabilityshowrobustlot-to-lotconsistencyareavailableinindustrial-scaleamountsareavailableascustomizedproductsforfilling,packagingandlabelingImmunogenTheimmunogenisdescribedbyitsfullnameorasanabbreviation(inbrackets)AnimalSpeciesB=bovine,RB=rabbit,M=mouse,S=sheep,H=humanPreparationRS=rawserumIgG(DE)=immunoglobulinfraction,purified,forexample,bydextranchromatographyIgG(IS)=immunoglobulinfraction,purifiedbyimmunosorptionF(ab)'2=fragment,derivedfrompepsindigestionofIgGFab=fragment,derivedfrompapaindigestionofIgGAntibodyNomenclatureImmunogenAnimalSpeciesPreparationPrimeTermMABM-Tu88E8IgG(DE)CloneGMPproductionbackmixreactorforfinalstagecrystallizationAntibodiesforClinicalChemistryCRPTestingC-reactiveprotein(CRP)isamemberoftheglobulinfamilyofhumanplasmaproteins.IncreasedlevelsofCRPareinvolvedinavarietyofinflammatorydiseases.ElevatedCRPserumlevelsindicatetissueinjury,transplantrejection,carcino-genesis,andacutemyocardialinfarction.SpecificationsAntibodyPABSIgGCatalogNumber11888714103AppearanceFrozensolutionImmunogenHumanC-reactiveproteinPurity(HPLC,MonoQ)90%IgGBioburden1000cfu/mlCalibrationcurvecharacterizationdA(turbidimetric.:A340/700)1mg/dl0.02510mg/dl0.23025mg/dl0.480Stability24monthsat–15to–25°C;avoidrepeatedfreeze/thawcyclesWorkingconcentration15mg/mlSpecificationsAntibodyMABTu88E8MABTu66C7CatalogNumber1154359810311543601103AppearanceLyophilizateImmunogenHumansalivaryamylaseSpleendonorMousebalb/cAntibodyclassIgG2a,kappaPurity(HPLC,MonoQ)90%IgGCross-reactivityh-pancreasamylase:1U/gWSynergisticeffectsat+37°Ch-salivaryamylase+MAB:3%amylaseactivityh-pancreasamylase+MAB:98%amylaseactivityStability36monthsat–15to–25°C;avoidrepeatedfreeze/thawcyclesInturbidimetric/nephelometricassays,PABSIgGiscoupledontolatexsurfaces.Theseaggregatescanbedetectedat340/700nm.TestComponentsCatalogNumberPABSIgG11888714103Trisbuffer10153265001N-Methylisothiazolone(MIT)11085905103TestComponentsCatalogNumberMABTu88E811543598103MABTu66C711543601103-Glucosidase116263291034,6-Ethylidene-G7PNP(EPS)10880078103Polidocanol10831620103N-Methylisothiazolone(MIT)11085905103Hepesbuffer10172944103ThecombinationofMABTu88E8andMABTu66C7inhibitsthehumansalivary-amylase97%,whilemaintainingtheactivityofthepancreatic-amylase.Pancreatic-AmylaseTestingInhumanserumandurine,thetwomajorisoenzymesofhuman--amylase,salivary(s)andpancreatic(p)amylase,arepresent.Forselectivemeasurementofacutepancreatitis,blockingofsalivation,-amylaseisnecessary.CreatineKinaseMBTestingCK-MBmeasurementisakeyparameterforthediagnosisofacutemyocardialinfarction.TheMABMixinhib-itstheCK-Msubunitbymorethan99.7%,allowin...