药源性牙龈增生VIP免费

中国现代应用药学2010年8月第27卷第8期ChinJMAP,2010August,Vol.27No.8·685·[7]MAEDAN,TAKEUCHIY,TAKADAM,etal.Anti-neovasculartherapybyuseoftumorneovasculature-targetedlong-circulatingliposome[J].JControlRelease,2004,100(1):41-52.[8]KATANASAKAAY,IDAAT,ASAIAT,etal.Effectivedeliveryofanangiogenesisinhibitorbyneovessel-targetedliposomes[J].InterJPharm,2008,360(1/2):219-224.[9]ASAIT,MIYAZAWAS,MAEDAN,etal.Antineovasculartherapywithangiogenicvesseltargetedpolyethyleneglycol-shieldedliposomalDPP-CNDAC[J].CancerSci,2008,99(5):1029-1033.[10]YANSR,WANGLL,QIUFC.Advancesincell-penetratingpeptides[J].LettersInBiotechnology(生物技术通讯),2006,17(5):796-798.[11]TORCHILINVP,LEVCHENKOTS.TAT-liposomes:anovelintracellulardrugcarrier[J].CurProteinPeptSci,2003,4(2):133-140.[12]DAGARS,KRISHNADASA,RUBINSTEINI,etal.VIPgraftedstericallystabilizedliposomesfortargetedimagingofbreastcancer:invivostudies[J].JControlRelease,2003,91(1/2):123-133.[13]TORCHILINVP.Targetedpharmaceuticalnanocarriersforcancertherapyandimaging[J].AAPSJ,2007,9(2):128-147.[14]ZHAOH,WANGJC,LUOCL,etal.InvitroevaluationofGRGDSpeptidemodifiedliposomescontainingpaclitaxel[J].ChinJNewDrugs(中国新药杂志),2008,17(23):2034-2038.[15]PASTORINOF,BRIGNOLEC,MARIMPIETRID,etal.Vasculardamageandanti-angiogeniceffectsoftumorvessel-targetedliposomalchemotherapy[J].CancerRes,2003,63(21):7400-7409.[16]LOA,LINCT,WUHC.Hepatocellularcarcinomacell-specificpeptideligandfortargeteddrugdelivery[J].MolCancerTher,2008,7(3):579-589.收稿日期：2009-11-02药源性牙龈增生雷招宝(丰城市人民医院，江西丰城331100)摘要：目的探讨药源性牙龈增生的致病机制及其防治方法，为临床合理用药提供参考。方法检索国内外有关文献，进行文献综述。结果引起药源性牙龈增生的药物主要有钙拮抗剂、抗癫痫药物和免疫抑制剂环孢素A等。致病机制多种多样，但主要与降低牙龈成纤维细胞表面α2β1整合素与胶原的亲和力、降低胶原的吞噬作用，从而导致Ⅰ型胶原的堆积有关。合理选药和保持口腔卫生是预防牙龈增生的有效方法，牙龈切除仍然是治疗严重牙龈增生的主要方法。结论药源性牙龈增生可影响咀嚼、语言、刷牙和美容，但一般无严重的临床后果，医务工作者和患者对药源性牙龈增生都应有所认识。关键词：牙龈增生；药源性疾病；钙拮抗剂；抗癫痫药物；免疫抑制剂；预防；处理中图分类号：R944.11文献标志码：A文章编号：1007-7693(2010)08-0685-05Drug-InducedGingivalOvergrowthLEIZhaobao(FengchengPeople’sHospital,Fengcheng331100,China)ABSTRACT:OBJECTIVEToinvestigatethepathogenicmechanismsandthemethodsofpreventionandcureofdrug-inducedgingivalovergrowth,andprovidetheinformationforrationaluseofdrugsinclinic.METHODSToretrieverelateliteraturesindomesticandabroad,andreviewtheliteratures.RESULTSThemaindrugsthatinducedgingivalovergrowtharecalciumantagonists,antiepilepticsandimmunosuppressiveagentscyclosporineA.Thepathogenicmechanismsofdrug-inducedgingivalovergrowtharemultiformity.Themainmechanismisreduceingtheaffinityofα2β1integrinandcollagen,andthephagocytosisofcollagen,andinducingaccumulationoftypeⅠcollagen.Reasonabledrugselectionandmaintainingoralhygienearetheeffectivemethodspreventingdrug-inducedgingivalovergrowth.Themainmethodoftherapyfordrug-inducedgingivalovergrowthisgingivectomy.CONCLUSIONDrug-inducedgingivalovergrowthmayaffectthemastication,speech,toothbrushingandphysiognomy,butthereisnotseriousclinicaloutcomes,anditshouldbelearnedbymedicalworkersandpatients.KEYWORDS:gingivalovergrowth;drug-induceddisease;calciumantagonists;antiepileptics;immunosup...