中国组织工程研究与临床康复多事胆卷第JD勇铲2008一03—04出版JournalofClinicalRehabilitativeTissueEngineeringResearchMarcht2008V01．12，No．10人工角膜及其相关材料：l=★严拓1，敖宁建1，覃百花1，邓华2ArtificialcorneaandrelatedmaterialsYanTu01，AoNing-jianl，TanBai-hual，DengHua2AbstractBACKGRoUND：Asforthepatientwhofailshomologouscornealimplantation．theonlyalternativeforrestoringvisionisartificialcornea．Aldioughthestudyofartificialcomeahasbeenstraddlingfortwocenturies，however，thesurgerycanbeonlycarriedoutinafewspecialcentersduetothelimitingfactors．Inrecentyears，astherapiddevelopmentofrelevantdisciplines，artificialcorneahasenteredarapiddevelopingperiod．oBJECTIVE：Toillustratethematedalchoice，structure。materialmodificationandclinicaltrialsoftheartificialcornea,comparethecharacteristicsofdifferentstructuresartificialcomea，pointoutthecurrentdisadvantagesofeachkindofcornea，andproposeareasonableprospecttotheidealartificialcornea．RETRIEVALSTRATEGY：Acomputer-basedsearchofChinaFull-textJournalDatabase．Springer,EI．BlackwellDatabasewasundertakentoidentifythearticlespublishedfromJanuary1993toDecember2007．withthekeywordsof”artificialcornea,penetratingkeratoplasty”inbothChineseandEnglish．Inclusivecriteria：articlesrelatedtothematerial，designandclinicalstudy0fartificialcornea．Exclusivecriteria：outdatedandrepetitionresearches．LITERATUREEVALUATIoN：Atotalof86articleswerecollected．including68mettheinclusivecriteria,inwhichtherewere12reviewarticles．37basicresearchesand19elinicalresearches．Finally30atticleswereselectedforreviews．DATASYNTHESIS：Thematerialsofartificialcomeaincludeopticalmaterials(hydrogel，polymethylmethacrylate，silicagel，glass)andscaffoldmaterials(fluorine—carbonpolymer,hydroxyapatiteceramic，biomaterial)．Materialsmodificationconsistsofchemicalmodification，surfacetreatment，andsurfaceplasmatreatment。etc'．11地SUCCESSfuldesignmodelsofartificialcolTleaareAlphaCorandOsteo-Odonto，whichhavebeenapprovedbytheAmericanFoodandDrugAdministrationandhaveappliedontheclinicalpractice．CONCLUSIoN：Thefurtherstudyshouldbefocusedonelevatingtheattachmentbetweenartificialcorneaandtissue．andreducingcomplications．Thechoice．modificationanddesignofthematerialsarethekeyselvement．YanT，AoNJ，TanBH，DengH．Artificialcorneaandrelatedmaterials．ZhonggnoZuzhiGongchengYanjiuyuLinchuangKangfll2008；12(10)：1903—1906(China)【www．zglckf．com／zglckf／ejoumal／upfilesd08-10／10k一1903(ps)．pdq摘要学术背景：对于同种异体角膜移植失败的患者，人工角膜移植便成了复明的惟一希望。人工角膜的研究虽然已经跨越2个世纪，但由于各种因素限制，角膜植入术仍然只能在少数中心开展。近年来，由于相关学科的飞速发展，人工角膜也进入了快速发展时期。目的：从材料选择、片型设计、材料改性以及l临床试验等角度进行叙述，比较不同结构人工角膜各自特点，并指出目前人工角膜所存在的主要问题，对理想的人工角膜提出了新的见解。检索策略：作者应用计算机检索中国全文期刊数据库(CNKI)，Springer，EI，BlackweU数据库1993-01／2007—12与人工角膜相关文献。所用中文检索词有”人工角膜、角膜穿透术”；英文检索词包括。artificialcornea,penetratingkeratoplasty”。纳入标准：文章内容与人工角膜材料、片型设计、临床研究有关。排除标准：较为陈旧，重复性研究。文献评价：共检索到86篇相关文献，68篇文献符合上述要求，其中12篇为综述性文献，37篇为基础性研究文献，19篇为临床研究文献，从中选择30篇进行综述。资料综合：人工角膜材料包括光学镜柱材料(水凝胶、聚甲...
