genesisafteracuteintravenousloadingwithethyleneglycolorgly-cineinratsreceivingstandardandvitaminB6-deficientdiets[J].IntJUrol,2008,15(10):929-935.[13]SharmaV,SchwillePO.ClofibratefeedingtoSprague-Dawleyratsincreasesendogenousbiosynthesisofoxalateandcauseshyperox-aluria[J].MetabClinExp,1997,46(2):135-139.[14]MdluliK,BoothMPS,BradyRL,etal.Apreliminaryaccountofthepropertiesofrecombinanthumanglyoxylatereductase(GRH-PR),LDHAandLDHBwithglyoxylate,andtheirpotentialrolesinitsmetabolism[J].BBA-ProteinsProteom,2005,1753(2):209-216.[15]GambaroG,BaggioB.Idiopathiccalciumoxalatenephrolithiasis:acellulardisease[J].ScanningMicrosc,1992,6(1):247-254.[16]BaggioB,GambaroG,PiccoliA,etal.Evidenceofalinkbetweenerythrocyteband3phosphorylationandaniontransportinpatientswith'idiopathic'calciumoxalatenephrolithiasis[J].MinerElectrolMetab,1993,19(1):17-20.[17]SaradhadeviV,SakthivelR,VedamoorthyS,etal.Alterationsinband3proteinandanionexchangeinredbloodcellsofrenalfail-urepatients[J].MolCellBiochem,2005,273(1/2):11-24.[18]SelvamR,DeviVS.Enhancedoxalatetransportinnucleatedredbloodcells[J].EurUrol,1998,33(1):124-128.[19]BijarniaRK,KaurT,SinglaSK,etal.Oxalate-mediatedoxidant-antioxidantimbalanceinerythrocytes:roleofN-acetylcysteine[J].HumExpToxicol,2009,28(4):245-251.[20]LemannJ,PleussJA,WorcesterEM,etal.Urinaryoxalateexcre-tionincreaseswithbodysizeanddecreaseswithincreasingdietarycalciumintakeamonghealthyadults[J].KidneyInt,1996,49(1):200-208.[21]SienerR,GlatzS,NicolayC,etal.Theroleofoverweightandobe-sityincalciumoxalatestoneformation[J].ObesRes,2004,12(1):106-113.[22]DaudonM,LacourB,JungersP.Influenceofbodysizeonurinarystonecompositioninmenandwomen[J].UrolRes,2006,34(3):193-199.[23]CirilloM,IudiciM,MarcarelliF,etal.Nephrolithiasisinpatientswithintestinaldiseases[J].GItalNefrol,2008,25(1):42-48.[24]AbrattVR,ReidSJ.Oxalate-degradingbacteriaofthehumangutasprobioticsinthemanagementofkidneystonedisease[J].AdvAp-plMicrobiol,2010,72:63-87.[25]CamiciM,BalestriPL,LupettiS,etal.Urinaryexcretionofoxalateinrenalfailure[J].Nephron,1982,30(3):269-270.[26]TracyCR,PearleMS.Updateonthemedicalmanagementofstonedisease[J].CurrOpinUrol,2009,19(2):200-204.[27]TaylorEN,StampferMJ,MountDB,CurhanGC:DASH-StyleDietand24-HourUrineComposition[J].ClinJAmSocNephro,2010,5(12):2315-2322.[28]TaylorEN,CurhanGC.Fructoseconsumptionandtheriskofkid-neystones[J].KidneyInt,2008,73(2):139-140.[29]KnightJ,AssimosDG,EasterL,etal.Metabolismoffructosetoox-alateandglycolate[J].HormMetabRes,2010,42(12):868-873.收稿日期:2011-06-26修回日期:2011-09-20铁代谢及铁过载孟昭升1※,贾红英2,吴学琼1,盛玲玲3(1.山东省淄博市中心医院血液科,山东淄博255036;2.山东省淄博市中心医院检验科,山东淄博255036;3.山东省淄博市市级机关医院检验科,山东淄博255036)中图分类号:R589.9文献标识码:A文章编号:1006-2084(2012)01-0043-04摘要:人体缺乏有效的铁“排泄机制”,机体铁稳态的维持主要通过调控其吸收、转运与储存来实现。现总结近10年铁调控的相关研究成果,从肠道铁的吸收,铁在细胞、组织及血浆中的相互转运,铁的储存,铁调控激素hepcidin及其相关调控因子等方面探讨维持铁稳态的分子学机制,并简述遗传性血色病相关的发病机制,为理解铁代谢疾病提供线索。关键词:铁;代谢;生理;过载IronMetabolismandOverloadMENGZhao-sheng1,JIAHong-ying2,WUXue-qiong1,SHENGLing-ling3.(1.DepartmentofHematology,ZiboCentralHospital,Zibo255036,China;2.DepartmentofLaborato-ry,ZiboCentralHospital,Zibo255036,China;3.DepartmentofLaboratory,Zib...