NCBI良心教程,寻找基因转录本序列及相关编码蛋白//提及NCBI我们大家都不陌生,研究物种基因功能可都靠它呢。在NCBI的快速搜索下,基因转录本序列以及相关编码蛋白信息那也是手到擒来。然而当我们查找某个基因的相关信息时,就会发现该基因有很多个转录本。所以尽管基因查询很简单,但要精确定位至怕己所需的转录本核酸序列及蛋白信息仍是一个问题,今天小编就手把手教大家如何通过经NCBI搞定此难题,以栗子为主,包学包会。步骤1.打开pubmed:https://www.ncbi.nlm.nih.gov/pubmed2•选择基因并输入你要查找的基因名称,这里以TP53基因为例:3.点击search进入该界面.©hta^IoQGeneCrealeRSSCi&ale温《?n.AchancedTabular*20perf-age-SeribyRJSIPTIUE*deridt&.*claar4.点击第SeaiTtiFlkert:hl.mn祁刊晒SeeTP閃lUMiXCX1茁ei仃tp53inHomo诃「•邓电口山门氐陀生:UW[:耳佃renn応口1也2r?匸rird5SearchregulisItems:1to20of詰餉OE:河ij蓝匚Im口r「日卯FICWfiif日E*Paoc-1nf17flNc-.d-■Mamfc'GenEID□tucr^liDnLaczrbcinAliasesMIMTPMLmnorpntainp63[hkirnD三可禹an占Chrumas.Dma17BCC7LFS1P53TPP63191VDID7157(hu«msn>]MC0CO017.11I7KM027^07550.CDMplemfini)■血tunrinrputsinp-S?(ffflfib-sChrnnosonie10T嗣曲ID:24042rioragiCLH(Hcrv.Pfra1'||NCOffilM4i.5ei8S293561^4291□ip51LumarpnLainp£3[Danior^naChrnnnD^Dma5hJC007116Cbrpe-3drf£3DUD226365.ID20&9fl(Z旳1曲日"].235fl2427..235S4005iftdDdOB.p53.ZQG111919ftij.blOdDE-ES3LuitiorpQteinp£3[CanifWgChramasDMB£.bJC006^37.3P53ID.403969旳沪ilE您记agf||■325EU0G.32^5149一个TP53进入以下界面鑿jB1LVResultsb'ftaxenTopOrgarii£m£|TI~EEHanaspiena|'J2DfjUuBfrumajlUT|'521Ratusnoi^egciis屮J3CUluSj3CUllLJ3E2ICnceLulus9i^ejs-bAllMhBrtaxa曲御More...FindrslirtBCIdatiSearehdeta.ilET?53[iLlFIALJ^JANUTP53tumorproteinp53[Homo辭p忡加世口血前口&neID7157updatedon2-Apr-2017SummaryOfficialSrinliQl□llicialFullN^vnoPrimarysjourcQSeerdalcdGenetfpeH&TSeqaEaiusOrgamismLinkageAhohno^nSumM.:k:J■HGNUHGWCHGHC伯的3En乂眄日ENSG[l0a[]Ci14151[]RjlM生伯TH讥qaOTTHLIhnGQODOOIEm窈prDteincodingREVIEWEDHoma狛pki■活Euks吁M3.Metazoa.Cl^rdsLa.Craniala.Veilebrala.EijLelec?1.omi.fdammaha.EutheriaEuarchoriluglires.Pnmatei:.H^p-loiitimi.CaLdnhini.Honnndav.l-bmQP53;BCC7.LE91TRPS3Thisgen?encodes?lumorsuppressorproreinctiniainingtrjnscriptionglactw?ton[M4Abinding,anddignnienzsticindoriBinBTheencodedpnolsnrespondstodri-pr??cellularsire$s?s-ton?guhr?expressionoMsrgAl1联沖卯irducmg1c>?icycle箭哙計apoptosissenescenMDMAmpgirorchanges,inmgratnlismMu^bnsinHiis胛口日assodal^dwitha旧rielyhuman站口饲畅includinghRreditmryesreergsuch9$Li-Fraunflnisyndgrre曲slicingtfthisgenegrdtheISAufBhemetsjxomotRRir?suhinmuhiptetr?i5cript旧limiTtEandisofarrns.Additionaliseformshave3Isobeanshown栢rasuttofnihBuseerfaltarnstBiranshtiDninrtHtioncodDnsFromirtenbc^Iranscnpt^nsnls(PTyllDs12&]?c462Q93727TI[pru-idedbyRe胃処Oac2016|RWUWCIall5.下拉到NCBIReferenceSequences(RefSeq)区域,mRNAandProtein(s)下显示的就是该基因的转录本及其编码的蛋白:JLZZj6.—直下拉会发现该基因共有15个转录本HUIMH2托丫閉」「HPMiaiHD.1cellulartumofantigenp53恆口formgidflflliMlmgteinaandthaii鬥口门心畑t田T|口匚可HQ门wfcg11£^12£3£3011沁his;REVIEWEDDe-5cnpt]Ofi石现卿诚s}CiMisen&Lis£D$UniProlKEk'RnwPmtuniProtKan-rEMBiRelai«lTranscrlpl^anantTHISr.anant:2Jusesanalternalesplicesiteinme5UTR,ccnparedto!/anant1TTilsiswrrfcaninmateIranslallonRom恤oin-TrameAUG抽nccdonsTheisorornir-3pressnt-3dInIhls^adanlfQ.alsokncr^n茁Oalta^pesaiphaorceltar-JpE^:re&ull5inTItan刖mticninihadcnatm*domstrean^tart...