肺癌的生物靶向治疗进展上海市肺科医院肿瘤科Current Anti-Cancer ApproachesSurgeryChemo-therapyRadiationHormonaltherapyTargetedtherapyRemove known tumor massesKill rapidly dividing tumor cells, including tumor cells in adjacent tissuesKill rapidly dividing tumor cellsInhibit the growth and survival of hormone-dependent tumor cellsSpecifically inhibit processes required for tumor cell growth Why do we need new anticancer agents?*1-year survival rateData from the EUROCARE II study80706050403020100Relative 5-yearsurvival rate (%)BreastColonKidneyLiverLung*OvaryPancreas1978–19801984–19861987–1989 What makes an ideal therapeutic target?•Present in the majority of patients with specific tumor type•Causative link with tumourigenesis•Essential function in tumor cellsAssessing novel targeted agentsTypical cytotoxicMTD OBD ToxicityAntitumoureffectEffectTargetDoseOBD >MTDAdapted from Rowinsky 2000TargetToxicityAntitumoureffectOBDMTDEffectOBD
