精品文档---下载后可任意编辑B7-H1、PTN 及 PI3K 在大肠黏膜癌变过程中的表达及临床意义的开题报告摘要目的：探讨 B7-H1、PTN 及 PI3K 在大肠黏膜癌变过程中的表达及其临床意义。方法：收集大肠黏膜癌组织及其相邻正常组织标本，采纳免疫组织化学法检测 B7-H1、PTN 及 PI3K 的表达情况，并分析其与临床病理特征的关系。结果：B7-H1、PTN 及 PI3K 在大肠黏膜癌组织中的表达明显高于相邻正常组织，且表达水平随癌组织的恶性程度逐渐升高。B7-H1、PTN 及 PI3K 的高表达与大肠黏膜癌的淋巴结转移、临床分期和预后密切相关。结论：B7-H1、PTN 及 PI3K 的高表达可作为大肠黏膜癌的分子标志物，对于大肠黏膜癌的诊断、治疗及预后评估具有重要意义。关键词：大肠黏膜癌；B7-H1；PTN；PI3K；免疫组织化学AbstractObjective: To investigate the expression and clinical significance of B7-H1, PTN and PI3K in the process of colorectal mucosal carcinogenesis.Methods: Colorectal mucosal cancer tissue and its adjacent normal tissue specimens were collected. The expression of B7-H1, PTN and PI3K were detected by immunohistochemistry, and the relationship between the expression and clinical pathological features was analyzed.Results: The expression of B7-H1, PTN and PI3K in colorectal mucosal cancer tissues was significantly higher than that in adjacent normal tissues, and the expression levels increased with the malignant degree of cancer tissues. The high expression of B7-H1, PTN and PI3K was closely related to lymph node metastasis, clinical stage and prognosis of colorectal mucosal cancer.Conclusion: The high expression of B7-H1, PTN and PI3K can be used as molecular markers for colorectal mucosal 精品文档---下载后可任意编辑cancer, and it is of great significance for the diagnosis, treatment and prognosis evaluation of colorectal mucosal cancer.Keywords: Colorectal mucosal cancer; B7-H1; PTN; PI3K; Immunohistochemistry
