精品文档---下载后可任意编辑正常高值血压者 MCP-1 和 MMPs/TIMPs 与亚临床靶器官损害的关系的开题报告【摘要】随着生活水平的提高及现代社会的加速进展，高血压已成为全球性的社会问题，其对心血管、肾脏等多个器官的影响已日益受到重视。本文旨在探讨正常高值血压者 MCP-1 和 MMPs/TIMPs 与亚临床靶器官损害的关系。通过文献归纳总结，发现正常高值血压者的 MCP-1 及MMPs/TIMPs 与亚临床靶器官损害存在一定关联。随着血压值的升高，血管发生器质性改变的同时，其内皮细胞会释放出 MCP-1、MMPs/TIMPs 等细胞因子，加速血管内膜的炎症反应及纤维化，进而导致心脏、肾脏等器官的亚临床损害。因此，对于正常高值血压者应及早发现并及时干预，为其避开罹患相关慢性病奠定基础。【关键词】正常高值血压；MCP-1；MMPs/TIMPs；亚临床靶器官损害【Abstract】With the improvement of living standards and the accelerated development of modern society, hypertension has become a global social problem, and its effects on multiple organs such as the cardiovascular and kidneys have received increasing attention. The purpose of this paper is to explore the relationship between MCP-1 and MMPs/TIMPs in normal high-value blood pressure group and subclinical target organ damage. Through literature induction and summary, it is found that there is a certain correlation between MCP-1 and MMPs/TIMPs in normal high-value hypertension and subclinical target organ damage. As blood pressure values increase, vascular organic changes occur, and endothelial cells release cytokines such as MCP-1 and MMPs/TIMPs, which accelerate the inflammatory response and fibrosis of the vascular intima, leading to subclinical damage to organs such as the heart and kidneys. Therefore, it is necessary to identify and intervene in normal high-value blood pressure groups as early as possible to lay the foundation for them to avoid related chronic diseases.【Keywords】Normal high-value blood pressure; MCP-1; MMPs/TIMPs; subclinical target organ damage
