目 录中文摘要............................................................1英文摘要............................................................21、文献综述.........................................................41.1 多原发癌定义及诊断标准.......................................41.2 多原发癌的发病原因...........................................41.2.1 遗传因素...................................................41.2.2 医源性因素.................................................41.2.3 环境生活因素...............................................51.3 多原发癌的治疗及预后.........................................51.4 小结与展望...................................................52、前 言.........................................................73、材料与方法.......................................................83.1 数据获取、计算 SIR 及其 95%CI..................................83.2 预后分析的病例选择..........................................83.2.1 入选标准..................................................83.2.2 排除标准..................................................93.3 研究变量的选择与分组........................................93.4 统计分析方法................................................93.4.1 卵巢癌患者发癌风险.........................................93.4.2 预后分析..................................................104、结 果........................................................114.1 基本特征....................................................114.2 卵巢癌患者发生不同肿瘤的风险................................124.3 卵巢癌首发 MPC 患者的生存分析................................134.3.1 Kaplan-Meier 分析.........................................134.3.2 Log-rank 检验.............................................144.4 卵巢癌首发 MPC 患者预后多因素分析...........................215、讨 论........................................................225.1 卵巢癌患者发癌风险.........................................225.2 生存分析........................
