2010年第12卷第10期(总第84期)1769卫生经济学成人变应性鼻炎患者症状及生活质量评估#曹瑞娟*,许昱*,陶泽璋,张怡,陈婉仪,邓爱玲(武汉大学人民医院耳鼻咽喉头颈外科,武汉430060)#基金项目:“十一五”国家科技支撑计划资助项目(2007BAI18B15)。*通讯作者:许昱,Email:xy37138@163.com,曹瑞娟,caoruijuan2009@163.com。作者简介;曹瑞娟(为第一作者),女,医学硕士,主要研究方向为鼻科学。【摘要】目的:评估成人变应性鼻炎(allergicrhinitis,AR)患者的症状和生活质量及两者的相关性,同时评估皮肤点刺试验结果与症状、生活质量的相关性。方法:用症状视觉模拟评分量表(visualanalogscale,VAS)评价患者的症状严重程度,用鼻结膜炎相关生活质量问卷(RhinoconjunctivitisQualityofLifeQuestionnaire,RQLQ)评价患者的生活质量,记录皮肤点刺试验结果,并进行统计学分析。结果:(1)VAS各项症状间比较有显著性差异(F=264.89,P<0.01),喷嚏是患者的首要症状(64.47±26.14)。(2)RQLQ7方面间及各项目间比较均有显著性差异(F=29.15,P<0.01;F=34.65,P<0.01),生活质量最受影响的方面是鼻部症状(2.72±1.68),评分最高的项目是喷嚏(3.27±1.49)。(3)两量表有显著相关,其中,难以入睡、夜间醒来次数、睡眠质量不高与鼻塞VAS评分呈正相关(r=0.310,P=0.000;r=0.323,P=0.000;r=0.329,P=0.000),工作效率下降、注意力难以集中与难以入睡、夜间醒来次数、睡眠质量不高呈正相关,无耐心或烦躁与鼻塞、喷嚏VAS评分呈正相关(r=0.228,P=0.001;r=0.145,P=0.036),易怒与鼻塞VAS评分呈正相关(r=0.180,P=0.009),因症状而感到尴尬与喷嚏VAS评分呈正相关(r=0.150,P=0.030)。(4)皮肤点刺试验结果与两量表均无显著相关。结论:成人AR患者鼻部症状的严重程度与其生活质量显著相关,其中鼻塞、喷嚏可能是影响患者生活质量的主要原因;变应原级别与症状严重程度及生活质量无显著相关。【关键词】鼻炎;变应性;生活质量;量表【中图分类号】R195.3;R765.21【文章标识码】A【文章编号】1009-0959(2010)10--1769-03AnalysisofSymptomsandQualityofLifeinAdultwithAllergicRhinitisCaoRui-juan,XuYu,TaoZe-zhang,etal.(DepartmentofOtorhinolaryngologyHeadandNeckSurgery,WuhanUniversityPeople'sHospital,Wuhan430060,China)【ABSTRACT】Objective:Toevaluatesymptomsandqualityoflifeinadultwithallergicrhinitis,andtoevaluatethecorrelationamongtheskinpricktestsresults,symptomsandqualityoflife.Methods:Visualanalogscale(VAS)wasusedtoassessthesymptomsseverity,rhinoconjunctivitisqualityoflifequestionnaire(RQLQ)wasusedtoassessqualityoflife,theskinpricktestsresultswererecorded,andstatisticsanalysiswascarriedoutamongthem.Results:(1)ThereweresignificantdifferencesamongtheitemsofVAS(F=264.89,P<0.01),sneezingwasthemajorsymptomsforadultpatients(64.47±26.14).(2)ThereweresignificantdifferencesamongthesevernaspectsofRQLQ(F=29.15,P<0.01),nasalsymptomsitemwasthemostaffecteditemsofqualityoflife(2.72±1.68),andthereweresignificantdifferencesamongalltheitemsofRQLQ(F=34.65,P<0.01),thescoreofsneezingitemswasthehighest(3.27±1.49).(3)VASwassignificantlycorrelatedwithRQLQ,moreover,thescoresofunabletogettosleep,wakeupduringthenightandlackofagoodnight’ssleepweresignificantlycorrelatedwithnasalblockageVASscore(r=0.310,P=0.000;r=0.323,P=0.000;r=0.329,P=0.000),thescoresofgetlessaccomplishedandcan’tconcentrateweresignificantlycorrelatedwiththescoresofunabletogettosleep,wakeupduringthenightandlackofagoodnight’ssleep,thescoreofimpatientwassignificantlycorrelatedwithnasalblockageandsneezingVASscores(r=0.228,P=0.001;r=0.145,P=0.036),thescoreofirritablewassignificantlycorrelatedwithnasalblockageVASscore(r=0.180,P=0.009),thescoreofembarrassedbysymptomswassignificantlycorrelatedwithsneezingVASscore(r=0.150,P=0.030).(4)Theresultsoftheskinpri...
