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学号：2014103020027姓名：杨靖TheSignalingPathwaysinCerebralIschemia-inducedneurogenesisNeurogenesisintheadultbrainSVZ:thesubventricularzone.physiologicalAction:odordiscriminationolfactorymemeorySGZ:thesubgranularzone.physiologicalAction:learning,memoryandneuropsychiatricdisordersNeurogenesisinCerebralIschemianeuralstemcells;neuralprogenitorcells;neuroblastsTheShhSignalingPathwayinIschemia-inducedNeurogenesisTheShhreceptorsPtcandSmoareexpressedintheadulthippocampusandinprogenitorsderivedfromthisregion.ExogenousShhincreasesneurogenesisintheSVZ.TheShhpathwayalsomediatesstroke-inducedneurogenesis.ThemiR-17-92clusterintheShhsignalingpathway.TheShhSignalingPathwayinIschemia-inducedNeurogenesisTheNotchSignalingPathwayinCerebralIschemia-inducedNeurogenesisVariousstudieshaveshownthatcomponentsoftheNotchpathwayareexpressedintheSVZandSGZoftheadultmammalianbrain.Intheischemicbrain,activationoftheNotchpathwayincreasesneuralprogenitorcellproliferatio.miR-124aintheNotchsignalingpathway.TheNotchSignalingPathwayinCerebralIschemia-inducedNeurogenesisTheBMPSignalingPathwayinCerebralIschemia-inducedNeurogenesisTheBMPSignalingPathwayandNoggininCerebralIschemia-inducedNeurogenesisBMPsarenegativelyregulatedbyNoggin.TheWntSignalingPathwayinCerebralIschemia-inducedNeurogenesisTheWntSignalingPathwayinCerebralIschemia-inducedNeurogenesisSeveralstudieshaveaddressedtheroleofWntsignalinginadultneurogenesis.CerebralischemiachangesexpressionofWntandBMPfamilygenesinSVZneuralprogenitorcells.NeurotrophicfactorsinCerebralIschemia-inducedNeurogenesis