α-突触核蛋白与帕金森病【摘要】α-突触核蛋白是一种中枢神经系统突触前表达的可溶性蛋白,与帕金森病的发病有密切的关系
α-突触核蛋白在各种生理,环境因素的影响下异常表达和聚集,通过一系列的氧化应激等生化反应,产生了对神经元的毒性作用,从而参与了帕金森病的发生
对α-突触核蛋白的化学性质,聚集的机制及其影响因素的了解与研究,将会十分有利于帕金森病的预防和治疗
【关键词】α-突触核蛋白;帕金森病;路易小体Alpha - synapse nucleoalbumin and Parkinson sicknessZHANGYanchaoZHANGNanDIAO Jianping【Abstract】Alpha - the synapse nucleoalbumin is thesoluble protein which one kind of central nervous systemsynapse, expresses, gets sick the morbidity with Parkinson tohave the close relationship
Alpha - the synapse nucleoalbuminin each physiology, under environmental factor's influenceexceptionally expresses and gathers, through biochemistry andso on a series of oxidized stress responded, has produced toneuron's toxic effect, thus participated in the occurrence whichParkinson gets sick
To Alpha-