中国组织工程研究与临床康复第15卷第6期2011–02–05出版JournalofClinicalRehabilitativeTissueEngineeringResearchFebruary5,2011Vol.15,No.6P.O.Box1200,Shenyang110004cn.zglckf.com10241DepartmentofMR,JiangsuProvinceHospitalofTCM,Nanjing210029,JiangsuProvince,China;2DepartmentofOrthopaedics,NanjingFirstHospitalAffiliatedtoNanjingMedicalUniversity,Nanjing210006,JiangsuProvince,ChinaCuiYan-an,Associatechiefphysician,DepartmentofMR,JiangsuProvinceHospitalofTCM,Nanjing210029,JiangsuProvince,Chinacya6902@sohu.comSupportedby:theGeneralProgramofNaturalScienceFoundationofJiangsuProvince,No.BK2009460*Received:2010-07-15Accepted:2010-12-221江苏省中医院MR室,江苏省南京市210029;2南京医科大学附属南京第一医院骨科中心,江苏省南京市210006崔延安,男,1969年生,江苏省建湖县人,汉族,1993年扬州大学医学院毕业,副主任医师,主要从事骨关节方面的影像学研究。Cya6902@sohu.com中图分类号:R394.2文献标识码:B文章编号:1673-8225(2011)06-01024-06收稿日期:2010-07-15修回日期:2010-12-22(20100715021/W·Q)骨髓间充质干细胞移植膝类风湿关节炎兔:关节滑膜体积和软骨厚度的MRI评价*崔延安1,刘钊1,刘红霞1,黄海青1,张全彬2Bonemarrowmesenchymalstemcellstransplantationintreatmentofrheumatoidarthritisinrabbitkneejoints:MagneticresonanceimagingofcartilagethicknessandsynoviumvolumeofthekneejointsCuiYan-an1,LiuZhao1,LiuHong-xia1,HuangHai-qing1,ZhangQuan-bin2AbstractBACKGROUND:Bonemarrowmesenchymalstemcells(BMSCs)haveimmunoregulatoryfunctionsandthepotentialmultipledifferentiations.Itcaninhibitinflammatoryreactionofrheumatoidarthritisandpromotetherepairofcartilagedamage.OBJECTIVE:ToobservethethicknessofcartilageandthevolumeofsynoviuminMRItoanalyzetheeffectsofBMSCstransplantationontreatmentofearlyrheumatoidarthritisinrabbits.METHODS:Forty-twoNewZealandwhiterabbitswereinducedbyinjectingovalbuminintorightkneejoints.MRandpathologyexaminationofkneejointsinsixrabbitsweredoneat4weeksafterinjection(beforetreatment).Theremainingthirty-sixrabbitswererandomlyandequallydividedintomodelgroupandBMSCstreatmentgroup.MRandpathologyexaminationofkneejointsof6rabbitsfromeithergroupweredoneat1,2,3monthsafterinjection.ThethicknessofcartilageandthevolumeofsynoviumofthekneejointsweremeasuredbyMRI,andpathohistologicalchangeswereobservedaswell.RESULTSANDCONCLUSION:Modelgroupafter1,2,3monthstreatmentshowedsynoviumthickeningandcartilagethinning,andhigherpathologicalscores,andexhibitedsynoviumthinningandcartilagethickening,andlowerpathologicalscoresinBMSCstreatmentgroup.ThecorrelationbetweenMRIandpathologywasremarkable.TheseindicatedthatMRIcanshowtheeffectofBMSCsontheearlyrheumatoidarthritis.CuiYA,LiuZ,LiuHX,HuangHQ,ZhangQB.Bonemarrowmesenchymalstemcellstransplantationintreatmentofrheumatoidarthritisinrabbitkneejoints:Magneticresonanceimagingofcartilagethicknessandsynoviumvolumeofthekneejoints.ZhongguoZuzhiGongchengYanjiuyuLinchuangKangfu.2011;15(6):1024-1029.[http://www.crter.cnhttp://en.zglckf.com]摘要背景:骨髓间充质干细胞具有显著的免疫调节功能和多向分化潜能,可抑制类风湿关节炎的炎症反应,促进软骨损伤的修复。目的:用骨髓间充质干细胞治疗兔早期类风湿关节炎,运用MRI观察软骨厚度及滑膜体积的改变,评价治疗效果。方法:选取42只新西兰大白兔,用卵蛋白制造类风湿关节炎模型,造模第4周(治疗前)取6只兔行MRI和病理检查以对照,余36只兔随机分模型组和骨髓间充质干细胞治疗组,两组于治疗后1,2,3个月分别选取6只兔行MRI和病理检查。对病变膝关节的滑膜体积和软骨厚度进行MRI测量及病理...