骨髓间充质干细胞移植膝类风湿关节炎兔：关节滑膜体积和软骨厚度的VIP免费

中国组织工程研究与临床康复第15卷第6期2011–02–05出版JournalofClinicalRehabilitativeTissueEngineeringResearchFebruary5,2011Vol.15,No.6P.O.Box1200,Shenyang110004cn.zglckf.com10241DepartmentofMR,JiangsuProvinceHospitalofTCM,Nanjing210029,JiangsuProvince,China;2DepartmentofOrthopaedics,NanjingFirstHospitalAffiliatedtoNanjingMedicalUniversity,Nanjing210006,JiangsuProvince,ChinaCuiYan-an,Associatechiefphysician,DepartmentofMR,JiangsuProvinceHospitalofTCM,Nanjing210029,JiangsuProvince,Chinacya6902@sohu.comSupportedby:theGeneralProgramofNaturalScienceFoundationofJiangsuProvince,No.BK2009460*Received:2010-07-15Accepted:2010-12-221江苏省中医院MR室，江苏省南京市210029；2南京医科大学附属南京第一医院骨科中心，江苏省南京市210006崔延安，男，1969年生，江苏省建湖县人，汉族，1993年扬州大学医学院毕业，副主任医师，主要从事骨关节方面的影像学研究。Cya6902@sohu.com中图分类号:R394.2文献标识码:B文章编号:1673-8225(2011)06-01024-06收稿日期：2010-07-15修回日期：2010-12-22(20100715021/W·Q)骨髓间充质干细胞移植膝类风湿关节炎兔：关节滑膜体积和软骨厚度的MRI评价*崔延安1，刘钊1，刘红霞1，黄海青1，张全彬2Bonemarrowmesenchymalstemcellstransplantationintreatmentofrheumatoidarthritisinrabbitkneejoints:MagneticresonanceimagingofcartilagethicknessandsynoviumvolumeofthekneejointsCuiYan-an1,LiuZhao1,LiuHong-xia1,HuangHai-qing1,ZhangQuan-bin2AbstractBACKGROUND:Bonemarrowmesenchymalstemcells(BMSCs)haveimmunoregulatoryfunctionsandthepotentialmultipledifferentiations.Itcaninhibitinflammatoryreactionofrheumatoidarthritisandpromotetherepairofcartilagedamage.OBJECTIVE:ToobservethethicknessofcartilageandthevolumeofsynoviuminMRItoanalyzetheeffectsofBMSCstransplantationontreatmentofearlyrheumatoidarthritisinrabbits.METHODS:Forty-twoNewZealandwhiterabbitswereinducedbyinjectingovalbuminintorightkneejoints.MRandpathologyexaminationofkneejointsinsixrabbitsweredoneat4weeksafterinjection(beforetreatment).Theremainingthirty-sixrabbitswererandomlyandequallydividedintomodelgroupandBMSCstreatmentgroup.MRandpathologyexaminationofkneejointsof6rabbitsfromeithergroupweredoneat1,2,3monthsafterinjection.ThethicknessofcartilageandthevolumeofsynoviumofthekneejointsweremeasuredbyMRI,andpathohistologicalchangeswereobservedaswell.RESULTSANDCONCLUSION:Modelgroupafter1,2,3monthstreatmentshowedsynoviumthickeningandcartilagethinning,andhigherpathologicalscores,andexhibitedsynoviumthinningandcartilagethickening,andlowerpathologicalscoresinBMSCstreatmentgroup.ThecorrelationbetweenMRIandpathologywasremarkable.TheseindicatedthatMRIcanshowtheeffectofBMSCsontheearlyrheumatoidarthritis.CuiYA,LiuZ,LiuHX,HuangHQ,ZhangQB.Bonemarrowmesenchymalstemcellstransplantationintreatmentofrheumatoidarthritisinrabbitkneejoints:Magneticresonanceimagingofcartilagethicknessandsynoviumvolumeofthekneejoints.ZhongguoZuzhiGongchengYanjiuyuLinchuangKangfu.2011;15(6):1024-1029.[http://www.crter.cnhttp://en.zglckf.com]摘要背景：骨髓间充质干细胞具有显著的免疫调节功能和多向分化潜能，可抑制类风湿关节炎的炎症反应，促进软骨损伤的修复。目的：用骨髓间充质干细胞治疗兔早期类风湿关节炎，运用MRI观察软骨厚度及滑膜体积的改变，评价治疗效果。方法：选取42只新西兰大白兔，用卵蛋白制造类风湿关节炎模型，造模第4周(治疗前)取6只兔行MRI和病理检查以对照，余36只兔随机分模型组和骨髓间充质干细胞治疗组，两组于治疗后1，2，3个月分别选取6只兔行MRI和病理检查。对病变膝关节的滑膜体积和软骨厚度进行MRI测量及病理...