ofNrf2isdeterminedbyatleasttwoseparateproteindomains,theredox-sensitiveNeh2degronandtheredox-insensitiveNeh6de-gron[J].BiolChem,2004,279(30):31556~31567[6]KatohY,ItohK,YoshidaE,etal.TwodomainsofNrf2coopera-tivelybindCBP,aCREBbindingprotein,andsynergisticallyacti-vatetransription[J].GenesCells,2001,6(10):857~868[7]Itoh,K.,Mochizuki,M.,Ishii,Y.,etal.MolecularmechanismsregulatingNrf2activationinresponsetochemicalstress[J].MolCellBiol,2004,4(37):36~45[8]Gong,P.,Stewart,D.,Hu,B.,etal.RoleofbachlandNrf2inup-regulationofthehemeoxygenase-1genebycobaltprotopor-phyrin[J].FASEBJ,2006,20(14):2651~2653[9]KobayashiA,OhtaT,YamamotoM.UniquefunctionoftheNrf2/keap1pathwayintheinducibleexpressionofantioxidantanddetoxif-yingenzynmes[J].MethodsEnzymol,2004,378(20):273~286[10]KenslerTW,WakabayashiN,BiswalS.CellsurvivalresponsestoenvironmentalstressesviatheKeap1Nrf2AREpathway[J].AnnuRevPharmacolToxicol,2007,4(7):89~116[11]MotohashiH,YamamotoM.Nrf2/Keap1definesaphysiological-lyimportantstressresponsemechanism[J].TrendsMol,2004,10(11):549~557[12]ZipperLM,MulcahyRT.TheKeap1BTB/POZdimerizationfunctionisrequiredtosequesterNrf2incytoplasm[J].BiolChem,2002,277(39):36544~36552[13]KenslerTW,WakabayashiN,BiswalS.CellsurvivalresponsestoenvironmentalstressesviatheKeap1Nrf2AREpathway[J].AnnuRevPharmacolToxicol,2007,4(7):89~116[14]KwakMK,WakabayashiN,GreenlawJL,etal.Antioxidantsen-hancemammalianproteasomeexpressionthroughtheKeap12Nrf2signalingpathway[J].MolCellBiol,2003,23(23):8786~8794[15]Y.Zhang,P.Talalay,C.G.Cho,etal.Amajorinducerofanti-carcinogenicprotectiveenzymesfrombroccoli:isolationandelu-cidationofstructure[J].ProcNatlAcadSciUSA,2002,8(9):2399~2403[16]ZhaoJ,KoboriN,AronowskiJ,etal.Sulforaphanereducesin-farctvolumefollowingfocalcerebralischemiainrodents[J].Neu-rosciLett.2006;39(3):108~112[17]ShihAY,LiP,MurphyTH.Asmall-molecule-inducibleNrf2-mediatedantioxidantresponseprovideseffectiveprophy-laxisagainstcerebralischemiainvivo[J].Neurosci,2005,2(5):10321~10335[18]ZhaoJ,KoboriN,AronowskiJ,etal.Sulforaphanereducesin-farctvolumefollowingfocalcerebralischemiainrodents.Neuros-ciLett.2006;39(3):108~112[19]JainAK,BloomDA,JaiswalAK.Nuclearimportandexportsig-nalsincontrolofNrf2[J].BiolChem,2005,280(32):29158~29168[20]Kraft,A.D,Johnson,D.A,Johnson,J.A.NuclearfactorE2-relatedfactor2-dependentantioxidantresponseelementacti-vationbytert-butylhydroquinoneandsulforaphaneoccurringpreferentiallyinastrocytesconditionsneuronsagainstoxidativein-sult[J].Neurosci,2004,2(4):1101~1112[21]Dhakshinamoorthy,S.,andPorter,A.G.Nitricoxideinducedtranscriptionalup-regulationofprotectivegenesbyNrf2viatheantioxidantresponseelementcounteractsapoptosisofneuroblasto-macells[J].BiolChem,2004,27(9):20096~20107[22]LeeJM,LiJ,JohnsonDA,etal.Nrf2,amultiorganprotector[J].FASEBJ,2005,19(9):1061~1066[23]ZhaoJ,KoboriN,AronowskiJ,etal.Sulforaphanereducesin-farctvolumefollowingfocalcerebralischemiainrodents[J].Neu-rosciLett,2006,39(3):108~112[24]Yangch.CurcuminupregulatestranscriptionfactorNrf2,HO-1expressionandprotectsratbrainsagainstfocalischemia[J].BrainResearch,2009,12(82):133~141[收稿日期:...