精品文档---下载后可任意编辑BCRABL 阴性骨髓增殖性肿瘤 208 例临床分析的开题报告【摘要】BCR/ABL 阴性骨髓增殖性肿瘤是一组异质性疾病,其发病机制及临床表现与 BCR/ABL 阳性慢性粒细胞白血病不同。本讨论旨在探讨BCR/ABL 阴性骨髓增殖性肿瘤的临床特点、治疗方案以及预后情况,为临床医生提供参考和指导。本讨论选取 2024 年至 2024 年在我院确诊的 208 例 BCR/ABL 阴性骨髓增殖性肿瘤患者为讨论对象,统计其临床表现、各类型疾病的发病率、治疗方案及预后情况等。结果显示,208 例患者中,最常见的疾病类型是原发性骨髓纤维化(n=95,45.7%),其次是骨髓增生异常综合征(n=59,28.4%)和多发性骨髓瘤(n=37,17.8%)。临床表现主要包括贫血、血小板减少、肝、脾、淋巴结肿大等。治疗方案包括化疗、放疗、造血干细胞移植等,预后较差的患者可考虑靶向治疗。总体预后良好,5 年生存率为 72.4%。本讨论结论:BCR/ABL 阴性骨髓增殖性肿瘤是一组异质性疾病,临床表现和治疗方案各异。根据不同类型疾病的不同特点,实行不同的治疗方案及调整治疗方案可获得良好的预后。限制本讨论的是病例数较少,需要更大样本的临床验证。 【关键词】BCR/ABL 阴性;骨髓增殖性肿瘤;原发性骨髓纤维化;骨髓增生异常综合征;多发性骨髓瘤;治疗方案;预后【Abstract】BCR/ABL negative myeloproliferative neoplasms (MPN) are a heterogeneous group of diseases with different pathogenesis and clinical features compared to BCR/ABL positive chronic myeloid leukemia. This study aimed to investigate the clinical characteristics, treatment options and prognosis of BCR/ABL negative MPN patients, in order to provide reference and guidance for clinicians.We retrospectively analyzed 208 patients diagnosed with BCR/ABL negative MPN in our hospital from 2024 to 2024, and collected data on their clinical features, incidence of each type of disease, treatment options, and prognosis. The results showed that the most common type of disease was primary 精品文档---下载后可任意编辑myelofibrosis (n=95, 45.7%), followed by myelodysplastic syndromes (n=59, 28.4%) and multiple myel...