生物材料修复组织工程颅骨缺损及其性能评价VIP专享VIP免费

中国组织工程研究与临床康复第14卷第8期2010–02–19出版JournalofClinicalRehabilitativeTissueEngineeringResearchFebruary19,2010Vol.14,No.8P.O.Box1200,Shenyang110004cn.zglckf.com1442DepartmentofNeurosurgery,GeneralHospitalofShenyangMilitaryAreaCommandofChinesePLA,Shenyang110016,LiaoningProvince,ChinaLiJin-jiang★,Master,Physician,DepartmentofNeurosurgery,GeneralHospitalofShenyangMilitaryAreaCommandofChinesePLA,Shenyang110016,LiaoningProvince,ChinaSSS5105@163.comCorrespondenceto:LiangYong,Professor,DepartmentofNeurosurgery,GeneralHospitalofShenyangMilitaryAreaCommandofChinesePLA,Shenyang110016,LiaoningProvince,ChinaReceived:2009-10-05Accepted:2010-01-05解放军沈阳军区总医院神经外科，辽宁省沈阳市110016李晋江★，男，1982年生，辽宁省沈阳市人，汉族，2006年中南大学湘雅医学院大学毕业，2009年大连医科大学与解放军沈阳军区总医院联合培养临床技能型医学硕士毕业，医师，主要从事神经外科常见疾病手术治疗研究。Dr.li@qq.com通讯作者：梁勇，教授，解放军沈阳军区总医院神经外科，辽宁省沈阳市110016中图分类号:R318文献标识码:B文章编号:1673-8225(2010)08-01442-05收稿日期：2009-10-05修回日期：2010-01-05(20100105018/W•Q)生物材料修复组织工程颅骨缺损及其性能评价★李晋江，梁勇，赵明光，谢鹏，郭学军EvaluationofbiomaterialfunctioninrepairoftissueengineeringskulldefectLiJin-jiang,LiangYong,ZhaoMing-guang,XiePeng,GuoXue-junAbstractOBJECTIVE:Toevaluatefunctionandapplicationofvariousbiomaterialsintissueengineeringrepairskulldefect,andtoseekareasonableskullsubstitutes.METHODS:Using“tissueengineering,skulldefect,stemcells,cytokines,composite”askeywordsinChinese,andusing“tissueengineering,skulldefect,mesenchymalstemcells,cytokines,materials”askeywordsinEnglish,acomputer-basedonlinesearchwasperformedforpublicationsfromJanuary1993toOctober2009.Articlesconcerningbiomaterialsandtissueengineeringskulldefectrepairwereincluded.ArticlesdescribingrepetitivestudyorMetaanalysiswereexcluded.Functionofvariousbiomaterialsintissueengineeringrepairskulldefectwasassessin17articles.RESULTS:Stemcelltechniqueistoobtainseedcellsfromafewmyeloidtissues.Followinginvitroinductionandamplification,cellsatacertainnumbercouldcompoundwithstents,andconstructtissue-engineeredboneinvitro.Thecellscouldsustainthebiologicalfeaturesofosteoblasts,andfusewithbonetissueintherecipientsite.Simultaneously,itcouldavoidtheoccurrenceofimmunologicalrejection.Twoorovermaterialswerecompoundedtogether,orbiomaterialsurfacereceivedvariousmodification.Thesecouldpromoteadhesionbetweencellsandmaterials,elevatecellbioactivityandmaintainbiologicalfunction.Followingmovedintoseedcellsusingsomevectors,thelatterossifiedinbonedefectsite,andsecretedsuitablebonegrowthfactor,inducedthedifferentiationofperipheralnon-orientedosteogenitorcellsintoorientedosteogenitorcells,whichcouldharvestadequateseedcellswithosteogenicactivityinashorttime,andacceleratethehealingofskulldefects.Thecompositemadebyusingthree-dimensionalvirtualimagingandcomputernumericalcontrolmodelingtechniqueshastheadvantagesofmedicalcomposite,preciseanatomicalconsistencywithsurroundingtissuesofskulldefects,andperfectappearance.CONCLUSION:Atpresent,nomaterialcanbeaccordedwiththerequirementofbonetissueengineering.Combinationofsomematerialsormodificationofbiomaterialsurfacecanpromoteadhesionofcellsandmaterials,elevatecellbiologicalactivity,andmaintainbiologicalfunction,whicharepresentlyhotfocusoftissueengineeringrese...