文章编号:2095-1116(2012)01-0062-03·基础医学·收稿日期:2011-09-28通讯作者:袁秀琴,联系电话:0734-8281364,E-mail:wtjysh@126.com.衡阳市2002~2009年围生儿先天性唇腭裂畸形监测分析周发平1,袁秀琴1,袁玉梅2(1.南华大学公共卫生学院社会医学与卫生事业管理研究室,湖南衡阳421001;2.衡阳市妇幼保健院信息科)摘要:目的了解衡阳市先天性唇腭裂畸形发病率及其动态变化,为制定先天性唇腭裂的预防措施提供参考依据。方法收集以医院为基础的出生缺陷监测资料,对2002~2009年衡阳市围生儿先天性唇腭裂监测资料进行分析。结果8年来衡阳市围生儿先天性唇腭裂畸形平均发病率为15.19/万,男性发病率为17.51/万,女性发病率为9.75/万,男女之比为1.79∶1,两者差异有显著性(P=0.000);城镇发病率为9.05/万,农村发病率为17.89/万,两者差异有显著性(P=0.000);春夏秋冬四季度发病率依次为25.32/万、9.24/万、9.63/万、19.32/万,四季度之间差异有显著性(P=0.031);孕妇各年龄组(<20岁,20~25岁,25~30岁,30~35岁,≥35岁)发病率分别为41.43/万、15.22/万、12.96/万、14.94/万、和48.58/万,孕妇各年龄组之间差异有显著性(P=0.000)。结论8年来衡阳市围生儿先天性唇腭裂发病率呈上升趋势;农村的先天性唇腭裂发病率明显高于城镇;冬春季节发病率高于夏秋季;孕妇年龄<20岁和≥35岁是先天性唇腭裂畸形的高发阶段。关键词:唇腭裂;出生缺陷监测;发病率中图分类号:R781.56文献标识码:AAnalysisontheInbornDefectDataofPerinatalWithChilopalatognathusintheCityofHengyangfrom2002to2009ZHOUFa-ping,YUANXiu-qin,YUANYu-mei(DepartmentofHealthServiceManagementofPublicHealthandCommunityMedicine,UniversityofSouthChina,Hengyang,Hunan421001,China)Abstract:ObjectiveTounderstandtheincidencerateofinbornchilopalatognathusanditsdynamicstatechangingforformulatingaprecautionofinbornchilopalatognathus.MethodsCollectedandanalyztheinborndefectdatainhospi-talinthecityofHengyangfrom2002to2009.ResultsTheaverageincidencerateofinbornchilopalatognathuswas15.19ineverytenthousand,theincidencerateofmalewas17.51ineverytenthousand,theincidencerateoffemalewas9.57ineverytenthousand,themale-femaleincidenceratewas1.79to1(P=0.000),thedifferencebetweenmanandfe-malewassignificant;thecityincidenceratewas9.05ineverytenthousand,thecountryincidenceratewas17.89ineverytenthousands,therewasasignificancebetweenthem(P=0.000);thefourthquarterincidenceratewas25.32,9.24,9.63,19.32ineverytenthousandrespectively,thefourthquarterincidencewassignificant(P=147.000,P=0.031);theinci-dencerateindifferentagegrouppregnantwomanwas65.81,15.22,12.96,9.51,56.29ineverytenthousandrespective-ly,thedifferencebetweenthemwassignificant(P=0.000).ConclusionTheincidencerateofinbornchilopalatog-nathusduringthe8yearsinHengyangcitywasrising;thecountryincidenceratewashigherthancitys;theincidencerateinwinterandspringwerehigherthansummerandautumns;theageofpregnantwomenlowerthan20andequalorhigherthan35wasthehighstageintheincidencerateofinbornchilopalatognathus.Keywords:chilopalatognathus;birthdefectsmonitoring;indidencerate先天性唇腭裂为先天发育畸形病之一,它不但影响患者容貌、语言、吞咽等功能障碍,也在不同程度上阻碍他们的社会交往、学习工作和日常生活。据报道,在新生儿中,每700个婴儿中就有一个患唇腭裂,其总体发病率约为1.82‰[1],这众多的缺陷儿给国家、社会、乃至整个家庭造成巨大的经济负担,更重要的是给患者蒙上心灵的阴影和心理缺陷,26JournalofMedicalScienceinCentralSouthChina,January2012,Vol.40,No.1已严重影响儿童身心健康及人口生存质量。鉴如此,本文对2002~2009年衡阳市各级医院出生缺陷监测唇腭裂...