上消化道大量出血的上消化道大量出血的诊断与鉴别诊断诊断与鉴别诊断AcommonmedicalconditionAcommonmedicalcondition250,000–500,000admissions/yearUSUGIbleedingincidence100/100,000adultsIncidenceincreases20-30foldfromthirdtoninthdecadeoflifeLGIbleedingincidence20/100,000adultsOverwhelminglydiseaseoftheelderlyGIbleedingstopsspontaneouslyin80%MorbidityDataMorbidityDataMajoritywillreceivebloodtransfusions2–10%requireurgentsurgerytoarrestbleedingAverageLOS4–7daysMortalityratesforUGIbleeding2–15%Mortalityforpatientswhodevelopbleedingafteradmissiontohospitalforanotherreasonis20–30%CostsCostsAveragehospitalcostsexceed$5,000peradmissionMostofthisforhospitalbedandICUstaysratherthanphysicianfees,bloodproducts,diagnostictests,ormedicationsReductionofhospitaladmissionsandLOShasgreatestpotentialtoreducecosts一、概念一、概念上消化道概念?一、概念一、概念上消化道大量出血概念部位出血量:指出血达全身血量的30%~50%时(1500~2000ml),临床上出现低血容量性休克,收缩压<10.7kPa(80mmHg),脉压差<3.3~4.0kPa(25~30mmHg)及脉搏快而弱(脉搏>120次/min),血红蛋白<70g/L,红细胞计数<3Х1012/L。出血速度?UGIbleeding:NomenclatureUGIbleeding:NomenclatureHematemesis25%Melenaalone25%,50–100ccofbloodwillrenderstoolmelenicHematochezia15%,seeninmassiveUGIhemorrhage“Redblood”hematemesis“Coffeeground”emesis二、病因二、病因按照发病机制可分为以下五类炎症性疾患:机械性疾患:血管性疾患:赘生物:全身性疾患:炎症性疾患炎症性疾患机械性疾患机械性疾患血管性疾患血管性疾患赘生物赘生物全身性疾患全身性疾患三、临床表现三、临床表现呕血与黑粪:急性失血所致的表现发热氮质血症血象变化原发病表现四、出血量和休克的估计四、出血量和休克的估计1、临床判断:粪便潜血阳性:5~10ml柏油便:60~100ml呕血:250~300ml中等量失血:出血占全身血容量的15%,约800ml大量失血:出血占全身血量的30%~50%,约1500~2000ml呕血呕血黑粪黑粪胃管内引流出血性液体胃管内引流出血性液体22、判断上消化道出血的血液学指标、判断上消化道出血的血液学指标失血量(%)血红蛋白(g/L)红细胞计数(×1012/L)血细胞比容10~15>100>4>0.42070~1003~40.35~0.4>30<70<3<0.333、休克指数、休克指数休克指数=脉搏/收缩压(mmHg),正常为0.54。休克指数=1,失血量为血容量的20%~30%休克指数=1.5~2,失血量为血容量的30%~50%44、中心静脉压(、中心静脉压(CVPCVP)测定:)测定:能反映患者血容量和活动性出血。正常范围:0.59~1.18kPa<0.49kPa或波动不稳,应考虑有活动性出血及液体量不足五、判断出血是否停止或再出血五、判断出血是否停止或再出血继续出血或再出血的指征:反复呕血黑便次数增多外周循环衰竭的表现CPV↓或波动血常规:RBC↓、Hb↓、MCV↓、网织红细胞↑在补液量和排尿量足够的情况下,BUN持续下降或再次升高内镜下见病灶部位或边缘有新鲜血或渗血选择性动脉造影见病变处有多染色区五、判断出血是否停止或再出血五、判断出血是否停止或再出血再出血可能的征兆:呕血者>仅有黑便者首次出血量大动脉破裂老年人伴有明显动脉硬化食管胃底静脉曲张破裂出血内镜下见病灶处隆起的红色小斑点或小血管,或假动脉瘤形成ScoringSystemforPredictingRebleedingaScoringSystemforPredictingRebleedingandMortalityndMortalityVariableScoreAge<60060-791>792ShockNone0Tachycardia1Hypotension2ComorbidityNone0CAD,CHF,othermajorcomorbidity1Renalfailure,liverfailure,malignancy2DiagnosisMalloryWeisstearornolesionobserved0Allotherdiagnoses1Malignantlesion2StigmasofrecenthemorrhageNoneorspotinulcerbase0BloodintheGItract,clot,visiblevesselinulcerbase2ScoringisnotBoringScor...