1新生儿黄疸诊治yaoyue28@sina.comPaediatrics&ChildHealth1999;4(2):161-164ReferenceNo.FN98-02RevisioninprogressMay2007Paediatrics&ChildHealth2007;12(5):1B-12BReferenceNo.FN07-02Guidelinesfordetection,managementandpreventionofhyperbilirubinemiaintermandlatepretermnewborninfants参考文献•Hyperbilirubinemiaisverycommonandusuallybenigninthetermnewborninfantandthelatepreterminfantat35to36completedweeks.•Criticalhyperbilirubinemiaisuncommonbuthasthepotentialforcausinglong-termneurologicalimpairment.Earlydischargeofthehealthynewborninfant,particularlythoseinwhombreastfeedingmaynotbefullyestablished,maybeassociatedwithdelayeddiagnosisofsignificanthyperbilirubinemia.高胆红素血症很常见，多为良性。危险的高胆红素血症并不常见，但是有潜在的导致长期神经损害的可能。•胆红素水平与胆红素脑病发生•Itisestimatedthat60%oftermnewbornsdevelopjaundiceand2%reachaTSBconcentrationgreaterthan340μmol/L(19.8mg/dl).•Acuteencephalopathydoesnotoccurinfull-terminfantswhosepeakTSBconcentrationremainsbelow340μmol/LandisveryrareunlessthepeakTSBconcentrationexceeds425μmol/L(24.85mg/dl).Abovethislevel,theriskfortoxicityprogressivelyincreases.Morethanthree-quartersoftheinfantsintheUnitedStateskernicterusregistry(between1992and2002)hadaTSBconcentrationof515μmol/L(30.1mg/dl)orgreater,andtwo-thirdshadaconcentrationexceeding600μmol/L(35mg/dl).•Evenwithconcentrationsgreaterthan500μmol/L(29.2mg/dl),therearestillsomeinfantswhowillescapeencephalopathy.•Kernicterus（核黄疸）:thepathologicalfindingofdeep-yellowstainingofneuronsandneuronalnecrosisofthebasalganglia（基底节）andbrainstemnuclei（脑干神经元）.•Acutebilirubinencephalopathy（急性胆红素脑病）:aclinicalsyndrome,inthepresenceofseverehyperbilirubinemia,oflethargy（昏睡）,hypotoniaand（肌张力减低）poorsuck,whichmayprogresstohypertonia(withopisthotonos（角弓反张）andretrocollis（颈后倾）)withahigh-pitchedcryandfever,andeventuallytoseizures（发作）andcoma.•Chronicbilirubinencephalopathy（慢性胆红素脑病）:theclinicalsequelaeofacuteencephalopathywithathetoidcerebralpalsy（手足徐动症样大脑麻痹）withorwithoutseizures,developmentaldelay,hearingdeficit,oculomotor（眼球运动异常）disturbances,dentaldysplasia（牙发育异常）andmentaldeficiency.•Severehyperbilirubinemia（严重的高胆红素血症）:atotalserumbilirubin(TSB)concentrationgreaterthan340μmol/Latanytimeduringthefirst28daysoflife.•Criticalhyperbilirubinemia（危险的高胆红素血症）:aTSBconcentrationgreaterthan425μmol/Lduringthefirst28daysoflife.具有危险因素人群中患者与非患者之比相当于不具有危险因素人群中患者与非患者之比的倍数•脱水，高渗，呼吸窘迫，水肿，早产，酸中毒，低白蛋白血症，缺氧，抽搐可增加急性脑病的发生率•与败血症的关系?•Allofthereasonsforthevariablesusceptibilityofinfantsarenotknown;however,dehydration,hyperosmolarity,respiratorydistress,hydrops,prematurity,acidosis,hypoalbuminemia,hypoxiaandseizuresaresaidtoincreasetheriskofacuteencephalopathyinthepresenceofseverehyperbilirubinemia,althoughreliableevidencetoconfirmtheseassociationsislacking.•Inaddition,someinfantswithseverehyperbilirubinemiaarefoundtohavesepsis,butbothsepsisandhyperbilirubinemiaarecommonintheneonatalperiod,andsepsisappearstobeuncommoninthewell-appearinginfantwithseverehyperbilirubinemia.黄疸的发生（总体发生情况）•Early(days1-2)-uncommon–Haemolyticjaundice(ABO,others)•Normal(days3-10)-verycommon–Uncomplicated–Complicated-seebelo...
