鞘内注射抗-脑源性神经营养因子对大鼠后足切割痛觉的影响的开题报告

精品文档---下载后可任意编辑鞘内注射抗-脑源性神经营养因子对大鼠后足切割痛觉的影响的开题报告【摘要】本讨论旨在探讨鞘内注射抗-脑源性神经营养因子（anti-brain-derived neurotrophic factor，anti-BDNF）对大鼠后足切割痛觉的影响。首先，使用手术方法将大鼠后足进行切割，经过数日的康复后，将大鼠随机分为两组。其中一组大鼠接受鞘内注射抗-BDNF，另一组接受生理盐水注射。通过痛觉测试仪对各组大鼠的痛觉敏感度进行检测，包括机械性触痛和热痛。结果显示，接受抗-BDNF 治疗的大鼠在机械性触痛和热痛测试中的表现均有所改善，表明抗-BDNF 可减轻大鼠后足切割引起的痛觉。本讨论的结果表明，抗-BDNF 可能是一种针对后足切割痛觉的有效治疗方法。【关键词】鞘内注射；抗-BDNF；大鼠；切割痛觉【Abstract】The aim of this study is to investigate the effect of anti-brain-derived neurotrophic factor (anti-BDNF) injected intrathecally on the cut-induced pain in rat hind paw. First, rat hind paw was cut by surgery, and after a few days of recovery, rats were randomly divided into two groups. One group received intrathecal injection of anti-BDNF, while the other group received saline injection. The pain sensitivity of each group of rats was detected by pain tester, including mechanical allodynia and thermal hyperalgesia. The results showed that the performance of rats treated with anti-BDNF was improved in both mechanical allodynia and thermal hyperalgesia tests, indicating that anti-BDNF could relieve the pain caused by hind paw cutting in rats. The results of this study suggest that anti-BDNF may be an effective treatment for cut-induced pain in rat hind paw.【Keywords】intrathecal injection；anti-BDNF；rat；cut-induced pain