精品文档---下载后可任意编辑黄芪多糖对慢性粒细胞白血病患者浆细胞样树突状细胞功能的影响的开题报告题目：黄芪多糖对慢性粒细胞白血病患者浆细胞样树突状细胞功能的影响摘要：慢性粒细胞白血病（CML）是一种由单核细胞系祖细胞引起的骨髓增生异常性疾病。浆细胞样树突状细胞（pDCs）是一种免疫系统的专门细胞，在抗病毒和抗肿瘤免疫中起着重要作用。本讨论旨在探究黄芪多糖对 CML 患者 pDCs 功能的影响。采纳流式细胞术检测 pDCs 表面标志物表达以及分泌干扰素 α 的能力。结果表明，黄芪多糖可促进CML 患者 pDCs 表面标志物 CD80、CD86 和 HLA-DR 的表达，并增强pDCs 分泌干扰素 α 的能力，提示黄芪多糖可以改善 CML 患者免疫功能。关键词：黄芪多糖；慢性粒细胞白血病；浆细胞样树突状细胞；干扰素 α；免疫功能Abstract: Chronic myeloid leukemia (CML) is a bone marrow disorder caused by abnormal proliferation of mononuclear cell progenitors. Plasmacytoid dendritic cells (pDCs) are specialized cells of the immune system that play an important role in antiviral and antitumor immunity. This study aimed to investigate the effect of Huangqi polysaccharide on the function of pDCs in CML patients. Flow cytometry was used to detect the expression of surface markers and the ability of pDCs to secrete interferon-alpha. The results showed that Huangqi polysaccharide can promote the expression of surface markers CD80, CD86, and HLA-DR on pDCs and enhance the ability of pDCs to secrete interferon-alpha in CML patients, suggesting that Huangqi polysaccharide can improve the immune function of CML patients.Keywords: Huangqi polysaccharide; chronic myeloid leukemia; plasmacytoid dendritic cells; interferon-alpha; immune function
