高血压患者心率变异性论文 【摘要】目的探讨福辛普利对原发性高血压患者心率变异性的影响。方法对 130 例健康查体者行 24h 动态心电图作为正常对比组，比较 256 例原发性高血压患者服福辛普利前后做 24h 动态心电图，分析心率功率谱时域和频域指标。结果原发性高血压患者低频和总频显著增加，低频与高频比值增大，高频减少。时域相邻正常R-R 间期标准差（SDNN）和 R-R 间期平均值的标准差（SDANN）明显下降，与正常对比组比较均差异有显著性。原发性高血压患者的昼夜变化差异也较正常对比组显著下降。经福辛普利治疗后，除有效降压外，患者的 SDNN、SDANN 和高频增加，总频、低频、低频与高频比值减小，与对比组和治疗前比较差异均有显著性，其昼夜变化规律亦显著部分恢复。结论福辛普利在降压的同时，可改善原发性高血压患者的心率变异性。 【关键词】福辛普利高血压心率变异性 Effectsoffosenoprilonheartratevariabilityofessentialhypertensivepatients 【Abstract】ObjectiveTostudytheeffectoffosenoprilonheartratevariabilityofessentialhypertensivepa-tients.MethodsTheheartratepowerspectraldensityandtime-domainwasanalyzedin130healthysubjectsandin256patientswithhypertensionbeforeandafterusingthefosenoprilwith24hourelectrocardiographicrecordings.Re-sultsThelowfrequencyandtotalfrequencyandratiobetweenlowfrequencyandhighfrequencyofhypertensivepa-tientsweresignificantlyhigherthanthatofcontrol，thehighfrequencyandstandarddeviationofnormal-to-normalintervals（SDNN）andstandarddeviationofthemeanofRRintervalsforeach5minperiodofthe24hourelectrocar-diographicrecordings（SDANN）weresignificantlylowerthanthatofcontrol.Thedegreeofday-nightchangede-creasedsignificantly.Aftertreatmentoffosenopril，inadditiontolowingthebloodpressure，theSDNN，SDANNandhighfrequencyofhypertensivepatientsweresignificantlyincreased.Thelowfrequencyandtotalfrequencyandratiobetweenlowfrequencyandhighfrequencyofhypertensivepatientsweresignificantlydecreased.Thedegreeofday-nightchangewaspartlyrestored.ConclusionWhenfosenoprillowersbloodpressure，itcanimprovesignificantlytheheartratevariabilityofessentialhypertensivepatients. 【Keywords】fosenoprilhypertensio...
