念珠菌感染特性及耐药性分析--医学检验本科学位论文

念珠菌感染特性及耐药性分析 摘 要目的 探讨念珠菌感染的特点及耐药性情况，为临床合理选用抗真菌药物提供实验室依据。方法 应用回顾性调查分折的方法，对我院 1 年间住院病人、门诊病人标本分离的 193 株念珠菌进行统计并对常用抗真菌药敏试验结果进行分折。结果 分离出的念珠菌以内科系统为主，共分离出 136 株(占 70.47%)；检出真菌最多的部位是呼吸道，占真菌标本的 76.17%；其种类以白色念珠菌及热带念珠菌为主，分别占 73.58%和 15.54%；药敏结果中：两性霉素 B、制霉菌素均有90%以上的敏感率，特比萘芬对白色念珠菌的敏感率仅 6.3%，但对热带念珠菌的敏感率为 100%。结论 加强临床真菌分离菌株对抗菌药物的耐药性关注，根据药敏试验合理应用抗真菌药物十分重要。关健词：念珠菌,感染特性, 耐药性ABSTRACTobjective To investigate the characteristic of Candida infection and examine the drug resistance condition, so as to provide assistance to the reasonable use of antifungal agents clinically. Methods To analyze the status of drug resistance of 193 strains of Candida, which were isolated from inpatients and outpatients of our hospital. Antifungal agents susceptibility test was done to know the drug resistance. Results The Candida isolated in our hospital were predominant from medical unit, 136 strains of Candida were identified(accounted for 70.47%); The specimens where detected Candida were mostly from respiratory tract, accounting for 76.17%. The Strains of Candida albicans and C. tropicalis had the highst detection rates, accounting for 73.58% and 15.54% respectively. The rates of susceptibility of Candida to Amphotericin B, Nystatin were more than 90%, and the rates of susceptibility to Terbinafine was only 6.3% for Candida albicans, but 100% for C. tropicalis. Conclusion Pay more attention to the drug resistance to the Candida isolated from the clinical. Antifungal agents should be selected reasonably according to the result ...