Tenascin、CD34在胆管癌组织中的表达及临床意义VIP专享

Tenascin、CD34 在胆管癌组织中的表达及临床意义 【关键词】 胆管癌 摘要：目的 探讨 Tenascin、CD34 在胆管癌的发生、进展中的作用和意义。方法 收集我院 1995 年-2025 年期间切除的胆管癌标本 33 例和正常胆管组织 4 例，采纳免疫组织化学 SP 方法，检测其 Tenascin、CD34的表达情况。结果 Tenascin 在胆管癌组织中的阳性表达率为%(27/33)，其中病理分级Ⅰ级、Ⅱ级、Ⅲ级的阳性率分别为%、%和%，但无显着性统计学差异()；在正常胆管组织中未检测到 Tenascin 表达。CD34 在胆管癌组织中广泛表达，在正常胆管组织中仅有少量表达，两者相比具有显着统计学差异()。结论 Tenascin 可以作为胆管癌的肿瘤标志应用于临床诊断， CD34 可作为预测肿瘤转移的一项重要指标。 关键词：胆管癌；Tenascin；CD34；免疫组织化学 Expression and clinical significance of tenascin and CD34 in human cholangiocarcinoma ABSTRACT: Objecive To investigate the role of tenascin and CD34 in occurence and development of cholangiocarcinoma. Methods The expression of tenascin and CD34 were examined in 33 patients, 16 males, 17 femalse, ranged 32-70 years with cholangiocancinoma and in 4 cases of normal bile duct tissue by SP immunohisto chemical technique. Results TN expression was located in the stroma of cholangiocarcinoma. The proportion of positive TN expression was %(27/33). The positive rate of pathologic grade Ⅰ, Ⅱ and Ⅲ were %, % and %, respectively. There was no significant difference among the three graded groups. TN expression wasnt detected in normal tissues (). CD34 showed widespread expression in cholangiocarcinoma tissues, but limited in normal bile duct, which showed significant difference (). Conclusion TN was over expressed in cholangiocarcinoma compared with negative expression in normal tissues, which suggested the diagnostic value of TN for cholangiocarcinoma. The levels of MVD marked by CD34 were significantly higher in cholangiocarcinom...