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ABSTRACT01: Parent-mediated social communication therapy for young children with autism (PACT):long-term follow-up of a randomised controlled trial.01、针对自闭症幼儿的父母介导的社区沟通疗法（PACT）：随机对照试验的长期随访杂志（THE LANCET）发表年份（2016）期刊影响因子（53.254）Background: It is not known whether early intervention can improve long-term autismsymptom outcomes. We aimed to follow-up the Preschool Autism Communication Trial(PACT), to investigate whether the PACT intervention had a long-term effect on autismsymptoms and continued effects on parent and child social interaction.Methods: PACT was a randomised controlled trial of a parent-mediated social communicationintervention for children aged 2–4 years with core autism. Follow-up ascertainment was doneat three specialised clinical services centres in the UK (London, Manchester, and Newcastle) ata median of 5.75 years (IQR 5.42–5.92) from the original trial endpoint. The main blindedoutcomes were the comparative severity score (CSS) from the Autism Diagnostic ObservationSchedule (ADOS)自闭症诊断观察量表 , the Dyadic Communication Assessment Measure(DCMA) of the proportion of child initiatiations when interacting with the parent, and anexpressive-receptive language composite. All analyses followed the intention-to-treat principle.Findings: 121 (80%) of the 152 trial participants (59 [77%] of 77 assigned to PACT interventionvs 62 [83%] of 75 assigned to treatment as usual) were traced and consented to be assessedbetween July, 2013, and September, 2014. Mean age at follow-up was 10.5 years (SD 0.8).Group difference in favour of 赞同 the PACT intervention based on ADOS CSS of log-oddseffect size (ES) was 0.64 (95% CI 0·07 to 1·20) at treatment endpoint and ES 0.70 (95% CI−0.05 t...