以EDCNHS为交联剂的丝素蛋白基大孔微载体的制备与研究的开题报告VIP专享

精品文档---下载后可任意编辑以 EDCNHS 为交联剂的丝素蛋白基大孔微载体的制备与讨论的开题报告摘要本文讨论了以 EDCNHS 为交联剂的丝素蛋白基大孔微载体的制备方法及其性能。在制备过程中，首先通过电泳沉积技术将丝素蛋白定向沉积在硅胶微球的表面上，然后使用 EDCNHS 作为交联剂进行交联，形成大孔微载体。通过扫描电镜和透射电镜观察载体的形貌和内部结构，发现微球表面均匀覆盖着丝素蛋白，并且重叠连接成孔道结构。同时，通过傅里叶变换红外光谱和 X 射线衍射分析，证实了交联反应的成功和载体的结晶状态。最后，评估了载体的药物释放性能，结果表明所制备的微载体对药物的释放具有可控性和持久性。关键词：丝素蛋白，交联剂，大孔微载体，药物释放AbstractThis paper studies the preparation method and properties of silk protein-based macroporous microcarriers using EDCNHS as a cross-linking agent. In the preparation process, silk protein was first oriented deposited on the surface of silica microspheres by electrophoretic deposition technology, and then cross-linked with EDCNHS to form macroporous microcarriers. The morphology and internal structure of the carriers were observed by scanning electron microscopy and transmission electron microscopy, and it was found that the surface of the microspheres was uniformly covered with silk protein, which overlapped and connected to form a pore structure. At the same time, Fourier transform infrared spectroscopy and X-ray diffraction analysis confirmed the successful cross-linking reaction and the crystalline state of the carrier. Finally, the drug release performance of the carrier was evaluated, and the results showed that the prepared microcarriers had controllable and sustained drug release.Keywords: silk protein, cross-linking agent, macroporous microcarriers, drug release